WormMine: Gene WBGene00222265

• WormBase Gene ID: WBGene00222265
• Gene Name: Bm2004
• Sequence Name: Bm2004
• Organism: Brugia malayi
• Automated Description: Is affected by 20-hydroxyecdysone based on proteomic studies. Is predicted to encode a protein with the following domains: NAD(P)-binding domain superfamily; short chain dehydrogenase; and Short-chain dehydrogenase/reductase SDR. Is an ortholog of C. elegans let-767 and members of the C. elegans stdh gene class including stdh-4. In C. elegans, let-767 is involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; long-chain fatty acid biosynthetic process; and steroid metabolic process.
• Biotype: SO:0001217
• Genetic Position: :±

1 Organism

• Name: Brugia malayi
• Taxon Id: 6279

0 Synonyms

Genomics

1 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:Bm2004.1	Bm2004.1		[unknown]

Other

1 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Bm2004	Bm2004		[unknown]

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

1 Data Sets

• WormBaseAcedbConverter

0 Downstream Intergenic Region

6 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly lower expression in L3 larva comparing to in adult.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:L3_vs_Adult_Downregulated
	Transcripts that showed significantly increased expression in male B. malayi 30 days after infecting gerbils, comparing to female B. malayi 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_M30_vs_F30
	Transcripts that showed significantly lower expression in L4 larva comparing to in microfilariae.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:L4_vs_Micro_Downregulated
	Transcripts that showed significantly increased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_M120_vs_F120
	Transcripts that showed significantly lower expression in L4 larva comparing to in adult.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:L4_vs_Adult_Downregulated
	Proteins that showed significantly increased expression in parasites exposed to 20-hydroxyecdysone.	An empirical filter of proteins with more than two peptides identified, a P value <0.05 and a greater than two-fold change of differential expression, was applied to the data. The Bonferroni correction was applied to correct the P value for the proteins analyzed.	WBPaper00049261:20-hydroxyecdysone_upregulated_protein

0 Expression Patterns

0 GO Annotation

0 Homologues

0 Locations

0 Ontology Annotations

0 Regulates Expr Cluster

0 Sequence

1 Sequence Ontology Term