WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0120532 glycosaminoglycan-protein linkage region biosynthetic process GO

Namespace  biological_process Obsolete  false
Description  The formation of a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate) on specific serine residues of a core protein, on to which dermatan sulfate, chondroitin sulfate, heparan sulfate or heparin glycosaminoglycans may be assembled to synthesise the corresponding proteoglycan.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

35 Parents

Identifier Name Description
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0008152 metabolic process A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
GO:0043170 macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0009058 biosynthetic process A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
GO:0019538 protein metabolic process The chemical reactions and pathways involving a protein. Includes protein modification.
GO:0009100 glycoprotein metabolic process The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
GO:1901135 carbohydrate derivative metabolic process The chemical reactions and pathways involving carbohydrate derivative.
GO:0009059 macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:1901137 carbohydrate derivative biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrate derivative.
GO:0009101 glycoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
GO:0036211 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
GO:0043412 macromolecule modification The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.
GO:0006790 sulfur compound metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
GO:0044272 sulfur compound biosynthetic process The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
GO:0030203 glycosaminoglycan metabolic process The chemical reactions and pathways involving glycosaminoglycans, any of a group of linear polysaccharides composed of repeating disaccharide units.
GO:0006022 aminoglycan metabolic process The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.
GO:0006493 protein O-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.
GO:0070085 glycosylation The covalent attachment and further modification of carbohydrate residues to a substrate molecule.
GO:0043413 macromolecule glycosylation The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.
GO:0006486 protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
GO:0006023 aminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.
GO:0006024 glycosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any one of a group of linear polysaccharides composed of repeating disaccharide units.
GO:0006029 proteoglycan metabolic process The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
GO:0015012 heparan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparan sulfate chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate).
GO:0030166 proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
GO:0030201 heparan sulfate proteoglycan metabolic process The chemical reactions and pathways involving heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids.
GO:0030202 heparin proteoglycan metabolic process The chemical reactions and pathways involving heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin proteoglycans are stored selectively in the secretory granules of mammalian mast cells.
GO:0050654 chondroitin sulfate proteoglycan metabolic process The chemical reactions and pathways involving chondroitin sulfate proteoglycans, which consist of a core protein linked to a chondroitin sulfate glycosaminoglycan. The chondroitin sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-D-glucuronic acid-beta-(1,3)-N-acetyl-D-galactosamine, the latter of which can be O-sulfated.

40 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0006493 GO:0120532
part of GO:0030210 GO:0120532
part of GO:0015012 GO:0120532
part of GO:0050651 GO:0120532
part of GO:0050650 GO:0120532
part of GO:0008150 GO:0120532
is_a GO:0008150 GO:0120532
part of GO:0006029 GO:0120532
part of GO:0008152 GO:0120532
is_a GO:0008152 GO:0120532
part of GO:0009100 GO:0120532
part of GO:0009101 GO:0120532
part of GO:0006024 GO:0120532
part of GO:1901135 GO:0120532
part of GO:0006790 GO:0120532
part of GO:0019538 GO:0120532
is_a GO:0044238 GO:0120532
is_a GO:0009987 GO:0120532
is_a GO:0070085 GO:0120532
is_a GO:0036211 GO:0120532
is_a GO:0006486 GO:0120532
part of GO:0044272 GO:0120532
is_a GO:0019538 GO:0120532
part of GO:0044238 GO:0120532
part of GO:0009058 GO:0120532
is_a GO:0043170 GO:0120532
part of GO:0009059 GO:0120532
part of GO:1901137 GO:0120532
part of GO:0006023 GO:0120532
part of GO:0006022 GO:0120532

2 Synonyms

Name Type
glycosaminoglycan-protein linkage region biosynthesis synonym
Glycosaminoglycan biosynthesis, linkage tetrasaccharide synonym