WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0140612 DNA damage sensor activity GO

Namespace  molecular_function Obsolete  false
Description  A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signaling response.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

9 Parents

Identifier Name Description
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0003676 nucleic acid binding Binding to a nucleic acid.
GO:0005515 protein binding Binding to a protein.
GO:0140299 molecular sensor activity Binding to a molecule and eliciting a change in the protein's activity in response to the intracellular level of that molecule.
GO:0098772 molecular function regulator activity A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.
GO:0003677 DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003684 damaged DNA binding Binding to damaged DNA.
GO:0140612 DNA damage sensor activity A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signaling response.

13 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
has part GO:0003684 GO:0140612
has part GO:0003684 GO:0140612
is_a GO:0140299 GO:0140612
is_a GO:0140299 GO:0140612
has part GO:0003676 GO:0140612
is_a GO:0003674 GO:0140612
has part GO:0003677 GO:0140612
has part GO:0005515 GO:0140612
has part GO:0005488 GO:0140612
is_a GO:0098772 GO:0140612
has part GO:0003674 GO:0140612
is_a GO:0140612 GO:0140664
is_a GO:0140612 GO:0140664

1 Synonyms

Name Type
DNA damage sensing activity synonym