WormMine: GOTerm GO:1902960 negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO

• Namespace: biological_process
• Obsolete: false
• Description: Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.

0 Cross References

0 Data Sets

1 Ontology

• Name: GO

0 Ontology Annotations

45 Parents

Identifier	Name	Description
GO:0009987	cellular process	Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150	biological_process	A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0003674	molecular_function	A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824	catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0044238	primary metabolic process	The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0008152	metabolic process	A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
GO:0043170	macromolecule metabolic process	The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0016787	hydrolase activity	Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
GO:0065007	biological regulation	Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0019222	regulation of metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0050794	regulation of cellular process	Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0060255	regulation of macromolecule metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0080090	regulation of primary metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0050789	regulation of biological process	Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0019538	protein metabolic process	The chemical reactions and pathways involving a protein. Includes protein modification.
GO:0140096	catalytic activity, acting on a protein	Catalytic activity that acts to modify a protein.
GO:0048519	negative regulation of biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0048523	negative regulation of cellular process	Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0051246	regulation of protein metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
GO:0050790	regulation of catalytic activity	Any process that modulates the activity of an enzyme.
GO:0065009	regulation of molecular function	Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0009892	negative regulation of metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0010605	negative regulation of macromolecule metabolic process	Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0051248	negative regulation of protein metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.
GO:0006508	proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
GO:0030162	regulation of proteolysis	Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
GO:0045861	negative regulation of proteolysis	Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
GO:0008233	peptidase activity	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
GO:0004175	endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
GO:0070001	aspartic-type peptidase activity	Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.

62 Relations

Relationship	Parent Term . Identifier	Child Term . Identifier
negatively regulates	GO:1902944	GO:1902960
is_a	GO:1902992	GO:1902960
is_a	GO:0010951	GO:1902960
is_a	GO:0065007	GO:1902960
negatively regulates	GO:1902944	GO:1902960
is_a	GO:1902991	GO:1902960
is_a	GO:0010466	GO:1902960
negatively regulates	GO:0004175	GO:1902960
regulates	GO:0043170	GO:1902960
regulates	GO:0016787	GO:1902960
is_a	GO:0051336	GO:1902960
is_a	GO:0080090	GO:1902960
regulates	GO:0019538	GO:1902960
is_a	GO:0052548	GO:1902960
is_a	GO:0052547	GO:1902960
regulates	GO:0003824	GO:1902960
negatively regulates	GO:0006508	GO:1902960
negatively regulates	GO:0003674	GO:1902960
is_a	GO:0048519	GO:1902960
regulates	GO:0004175	GO:1902960
is_a	GO:0060255	GO:1902960
negatively regulates	GO:0043170	GO:1902960
is_a	GO:0051346	GO:1902960
negatively regulates	GO:0070001	GO:1902960
regulates	GO:0006508	GO:1902960
negatively regulates	GO:0003824	GO:1902960
regulates	GO:0003674	GO:1902960
negatively regulates	GO:0008233	GO:1902960
is_a	GO:0009892	GO:1902960
negatively regulates	GO:0008152	GO:1902960

179 Synonyms

• Name: downregulation of carboxyl protease activity involved in APP catabolic process
• Type: synonym

• Name: downregulation of carboxyl protease activity involved in APP catabolism
• Type: synonym

• Name: inhibition of aspartate protease activity involved in amyloid precursor protein breakdown
• Type: synonym

• Name: inhibition of aspartate protease activity involved in amyloid precursor protein catabolic process
• Type: synonym

• Name: inhibition of aspartate protease activity involved in amyloid precursor protein catabolism
• Type: synonym

• Name: inhibition of aspartate protease activity involved in amyloid precursor protein degradation
• Type: synonym

• Name: inhibition of aspartate protease activity involved in APP catabolic process
• Type: synonym

• Name: inhibition of aspartate protease activity involved in APP catabolism
• Type: synonym

• Name: inhibition of aspartic endopeptidase activity involved in amyloid precursor protein breakdown
• Type: synonym

• Name: inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process
• Type: synonym

• Name: inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolism
• Type: synonym

• Name: inhibition of aspartic endopeptidase activity involved in amyloid precursor protein degradation
• Type: synonym

• Name: inhibition of aspartic endopeptidase activity involved in APP catabolic process
• Type: synonym

• Name: inhibition of aspartic endopeptidase activity involved in APP catabolism
• Type: synonym

• Name: inhibition of aspartic protease activity involved in amyloid precursor protein breakdown
• Type: synonym

• Name: inhibition of aspartic protease activity involved in amyloid precursor protein catabolic process
• Type: synonym

• Name: inhibition of aspartic protease activity involved in amyloid precursor protein catabolism
• Type: synonym

• Name: inhibition of aspartic protease activity involved in amyloid precursor protein degradation
• Type: synonym

• Name: inhibition of aspartic protease activity involved in APP catabolic process
• Type: synonym

• Name: inhibition of aspartic protease activity involved in APP catabolism
• Type: synonym

• Name: inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown
• Type: synonym

• Name: inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
• Type: synonym

• Name: inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism
• Type: synonym

• Name: inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation
• Type: synonym

• Name: inhibition of aspartic-type endopeptidase activity involved in APP catabolic process
• Type: synonym

• Name: inhibition of aspartic-type endopeptidase activity involved in APP catabolism
• Type: synonym

• Name: inhibition of aspartyl protease activity involved in amyloid precursor protein breakdown
• Type: synonym

• Name: inhibition of aspartyl protease activity involved in amyloid precursor protein catabolic process
• Type: synonym

• Name: inhibition of aspartyl protease activity involved in amyloid precursor protein catabolism
• Type: synonym

• Name: inhibition of aspartyl protease activity involved in amyloid precursor protein degradation
• Type: synonym