WormMine: ExpressionPattern Expr1589

• Pattern: In worms that overexpress EGL-10 from a multicopy array of egl-10 transgenes, EGL-10 was detected in neural cell bodies as well as neural processes of these animals, either because overexpression raised the level of EGL-10 protein in cell bodies above the threshold of detection or because overexpression of EGL-10 exceeded the capacity of neurons to localize the protein to processes. A large number of neurons in the major ganglia of the head region expressed EGL-10. In addition, examination of the ventral cord neurons, lateral neurons, and tail ganglia suggested that most if not all neurons in C. elegans expressed EGL-10. In particular, the HSN motor neurons, expressed EGL-10. Staining observed in the nerve ring, ventral nerve cord, and dorsal nerve cord of wild-type animals.
• Primary Identifier: Expr1589
• Remark: Body wall muscles were also stained. The staining did not disappear in egl-10 null animals but it was strengthened in egl-10 overexpression lines.
• Subcellular Localization: The stained structures consisted of bundles of neural processes and were at the locations of the majority of the chemical synapses in the animal. In neurons, EGL-10 protein appeared to be localized exclusively to processes; no staining was seen in the neural cell bodies of wild-type animals. Animals at all stages of development from first stage larvae to adults showed similar staining of neural processes.

2 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion.	body wall musculature	body muscle	WBbt:0005813
Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses.	neuron	neurone	WBbt:0003679

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00001179	egl-10	F28C1.2	Caenorhabditis elegans

1 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	All C. elegans development stages, including embryo, larva and adult stage.		all stages Ce	WBls:0000002