| Primary Identifier | Expr11229 | Subcellular Localization | Immunofluorescence experiments using an antibody against the DSB-2 protein showed that DSB-2 localizes to chromatin in germ cell nuclei from meiotic entry to mid-pachytene. DSB-2 staining is first detected in the transition zone (TZ; corresponds to leptotene and zygotene stages, when pairing and SC assembly occur), and is strongest overall in early pachytene, where it localizes to chromatin in an uneven pattern, showing a few bright patches per nucleus as well as fainter stretches/foci associated with most of the chromatin. Towards mid-pachytene, the bright patches diminish and the chromatin signal fades and then disappears from most nuclei. However, in a subset of nuclei in the mid/late pachytene region, DSB-2 staining becomes brighter, with bright stretches/foci along most of the chromatin; a few of these 'outlier' brightly-staining nuclei are present in later pachytene and likely represent nuclei destined for apoptosis. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| a cell, of either sex, directly concerned in the production of a new organism. | germ cell | WBbt:0006796 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00194892 | dsb-2 | F26H11.6 | Caenorhabditis elegans |
