WormMine: ExpressionPattern Expr11179

• Pattern: Expression of cwn-2 Wnt ligand decreases during aging. The cwn-2/Wnt expression was observed all along the anterior-posterior body axis of the animal in body-wall muscles. The authors did not detect any expression in ventral cord motor neurons or intestinal cells as was previously observed during worm development (Gleason et al. 2006). By qPCR the authors found that total expression levels for both Wnt ligands significantly increased between day 2 and 5 of adulthood. In addition, expression of mom-2/Wnt is highly increased in posterior intestinal cells, but remains unchanged or may be even decreased in other tissues, where the authors failed to detect any expression using their transcriptional reporters.
• Primary Identifier: Expr11179

2 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages.	intestine	gut	WBbt:0005772
Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion.	body wall musculature	body muscle	WBbt:0005813

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00000858	cwn-2	W01B6.1	Caenorhabditis elegans

0 Life Stages