| Pattern | In early embryos, CAND-1 is expressed in all cells, predominantly in the nucleus. Embryonic staining is strongest during early stages and is reduced in late-stage embryos. The observation of CAND-1 protein in the one-cell stage zygote indicates that CAND-1 is provided as maternal product by the hermaphrodite parent. During larval stages, CAND-1 is observed in proliferative cell lineages, including the seam cells, intestine, P-lineage cells, somatic gonad, and germline. CAND-1 is also observed in a subset of non-proliferative tissues, including hypodermal cells, rectal epithelia and neuronal cells in the head and tail. In older adults, anti-CAND-1 staining is restricted to the intestine and germline, with the strongest staining in oocyte nuclei. In younger adults, faint vulval cell staining is observed, potentially reflecting the perdurance of CAND-1 protein from the L4 larval stage. The absence of CAND-1 expression in the majority of adult somatic tissues suggests that CAND-1 is not required for tissue homeostasis in the adult. | Primary Identifier | Expr9095 |
| Remark | Picture: Fig 2. RNAi depletion of CAND-1 significantly decreased the anti-CAND-1 signal, indicating that the staining is specific. | Subcellular Localization | Expressed in nucleus |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| a cellular object that consists of subcellular components, expresses genes or functions. | Cell | Cell type | WBbt:0004017 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00013606 | cand-1 | Y102A5A.1 | Caenorhabditis elegans |
