WormMine: ExpressionPattern Expr814

• Pattern: SAD-1::GFP fluorescence was most prominent in the nerve ring and the ventral and dorsal cords, regions of the axon where the majority of synapses are made. Little or no staining was observed in the sensory dendrites or the axonal commissures, which are devoid of synapses. Weaker fluorescence was also visible in the neuronal cell bodies excluded from the nucleus.
• Primary Identifier: Expr814
• Remark: Both wild-type SAD-1 and this GFP fusion caused paralysis and other phenotypes when expressed at high concentrations, but at the lower concentrations examined in this experiment punc-115SAD-1::GFP did not cause locomotion defects.
• Subcellular Localization: Little or no staining was observed in the sensory dendrites or the axonal commissures, which are devoid of synapses. Weaker fluorescence was also visible in the neuronal cell bodies excluded from the nucleus. Fluorescence appeared as a combination of punctate and diffuse staining within the axon.

3 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
a large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring.	ventral nerve cord	ventral cord	WBbt:0005829
the most extensive region of neuropil in the animal, consists of a large toroidal bundle of processes.	nerve ring	circumpharyngeal nerve ring	WBbt:0006749
a bundle of nerve processes that runs along the dorsal mid-line of the animal.	dorsal nerve cord	dorsal cord	WBbt:0006750

2 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00004719	sad-1	F15A2.6	Caenorhabditis elegans
WBGene00006839	unc-115	F09B9.2	Caenorhabditis elegans

0 Life Stages