WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

Expression Pattern :

Pattern  OOC-5 localization was observed in all cells of early wild-type embryos, in a pattern that changed with the cell cycle. Primary Identifier  Expr1735
Remark  early embryo (author) = blastula embryo (curator) --wjc. Subcellular Localization  In early one-cell interphase and prophase embryos, OOC-5 was enriched around the rim of both pronuclei, as well as being dispersed throughout the cytoplasm in a slightly reticular pattern. A similar distribution was seen in two-cell interphase and prophase embryos. Double labeling with antibodies against tubulin showed that regions of more concentrated OOC-5 staining corresponded to the areas of the microtubule asters. During metaphase in one- and two-cell embryos, OOC-5 remained perinuclear and was also associated with the poles of the mitotic spindle. Upon onset of anaphase, OOC-5 localized on the entire mitotic spindle. The transition from perinuclear OOC-5 localization to general spindle localization coincides precisely with nuclear envelope breakdown in C. elegans. Similar patterns of OOC-5 localization were observed in four-cell embryos, depending on the stage of the cell cycle. In addition, OOC-5 was enriched at the regions of cell-cell contact in some two-cell embryos (40%, n=41) and virtually all four-cell embryos examined (96%, n=24).
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7 Anatomy Terms

Definition Name Synonym Primary Identifier
Single cell zygote P0 lineage name: Z WBbt:0004422
embryonic cell ABa   WBbt:0005906
embryonic cell ABp   WBbt:0005994
Embryonic founder cell AB AB blastomere WBbt:0004015
embryonic cell EMS   WBbt:0006876
embryonic founder cell Psub1 lineage name: P0.p WBbt:0006874
embryonic founder cell Psub2 lineage name: P0.pp WBbt:0006873

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003870 ooc-5 C18E9.11 Caenorhabditis elegans

1 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The C. elegans life stage spanning 0-100min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 28 cells. From first cleavage until the start of gastrulation. blastula embryo Ce WBls:0000005