1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00003916 | par-1 | H39E23.1 | Caenorhabditis elegans |
| Primary Identifier | Expr9676 | Subcellular Localization | Before pronuclear formation, GFP::PAR-1 was uniformly distributed in the cytoplasm and weakly on the cortex (data not shown). At pronuclear formation, GFP::PAR-1 levels increased in the central cytoplasm and decreased in the peripheral cytoplasm. During pronuclear migration, GFP::PAR-1 levels remained low in the anterior-peripheral cytoplasm but increased in the posterior cytoplasm and on the posterior cortex. By nuclear envelope breakdown (NEBD), GFP::PAR-1 was enriched on the posterior cortex and formed a 3-fold anterior-low/posterior-high gradient in the cytoplasm, paralleling the gradient in MEX-5 diffusivity. Immunostaining of wild-type (WT) embryos with an anti-PAR-1 antibody confirmed the presence of a PAR-1 gradient in the cytoplasm of zygotes at NEBD. PAR-1 also localizes on centrosomes (bright dots) as reported previously ( Gnczy et al., 2001). |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00003916 | par-1 | H39E23.1 | Caenorhabditis elegans |
