WormMine: ExpressionPattern Expr11870

• Primary Identifier: Expr11870
• Remark: Temporal description
• Subcellular Localization: TOE-2 localizes to the centrosomes and plasma membrane of dividing neuroblasts and concentrates in the cleavage furrow as division proceeds. Before the Q division, TOE-2::GFP localized diffusely in the cytoplasm and was concentrated in the nucleus. Around metaphase, TOE- 2::GFP localized to the centrosomes. The protein remained at the centrosomes throughout the rest of the division and was inherited by both daughter cells. Before anaphase, TOE-2 also localized near the region of the membrane that eventually forms the furrow. As anaphase continued, TOE-2 concentrated within the furrow and remained there, eventually localizing to the midbody. During telophase, TOE-2 localized to chromatin. After abscission of the daughter cells, TOE-2 was again diffuse in the cytoplasm and highly concentrated in the nucleus. In Q.a and Q.p - as in the Q cell - TOE-2 localized to centrosomes, to the region of the cortex in which the furrow forms, to the furrow and, at a later stage, to the midbody. In contrast with the localization of TOE-2::GFP to the chromatin of Q daughter cells, the protein did not appear to accumulate near chromatin, or in nuclei, of the daughter cells of Q.a and Q.p during, or after, telophase.

6 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Postembryonic neuroblast, migrates posteriorly.	QL	lineage name: ABplapapaaa	WBbt:0004056
Postembryonic neuroblast, migrates anteriorly.	QR	lineage name: ABprapapaaa	WBbt:0004054
post-embryonic cell of pedigree QR.a	QR.a		WBbt:0007279
post-embryonic cell of pedigree QR.p	QR.p		WBbt:0007281
post-embryonic cell of pedigree QL.a	QL.a		WBbt:0007274
post-embryonic cell of pedigree QL.p	QL.p		WBbt:0007276

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00016971	toe-2	C56E6.3	Caenorhabditis elegans

0 Life Stages