WormMine: ExpressionPattern Expr1604

• Pattern: HAM-1 is first expressed at the onset of gastrulation, approximately 100 minutes after cleavage of the zygote. At this time, HAM-1 often localizes to the periphery of cells in crescent shaped patterns that are restricted to one side of dividing cells. HAM-1 expression persists until the 1.5 fold stage of embryonic development, approximately 430 minutes after cleavage of the zygote. No HAM-1 expression can be detected later during embryonic or larval hermaphrodite development. HAM-1 protein is expressed in many mitotic and postmitotic cells. To determine whether HAM-1 is expressed in the lineage that produces the HSN and PHB neurons, embryos were stained at 260-300 minutes after cleavage of the zygote. HAM-1 is restricted to the posterior half of the HSN/PHB neuroblast. After division of the HSN/PHB neuroblast, HAM-1 ring staining can occasionally be seen in cells that, by position, could be the HSN/PHB precursor. This staining, however, is usually not detectable suggesting that HAM-1 is degraded rapidly after division of the HSN/PHB neuroblast.
• Primary Identifier: Expr1604
• Subcellular Localization: HAM-1 expressed in cells at metaphase. Chromosomes are condensed and HAM-1 is distributed to one side of the cell. HAM-1 expressed in cells at telophase. Two nuclear envelopes have reformed and HAM-1 is distributed to the side of the cell that will be inherited with the posterior nucleus. HAM-1 staining also appears as rings that surround cells. HAM-1 often localizes to the periphery of cells in crescent shaped patterns that are restricted to one side of dividing cells.

1 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
A blast cell from which a neuron develops.	neuroblast		WBbt:0008594

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00001820	ham-1	F53B2.6	Caenorhabditis elegans

5 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The C. elegans life stage spanning 290-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage when embryo just finished gastrulation and is enclosing.		enclosing embryo Ce	WBls:0000013
	The C. elegans life stage spanning 100-290min after first cleavage at 20 Centigrade. Proliferate from 28 cells to 421 cells. Referring to the whole period of gastrulation.		gastrulating embryo Ce	WBls:0000010
	The C. elegans life stage spanning 390-420min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo looks like a comma. A stage between bean embryo and 1.5-fold embryo.		comma embryo Ce	WBls:0000017
	The C. elegans life stage spanning 420-460min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and fold back 50%. A stage between comma embryo and 2-fold embryo.		1.5-fold embryo Ce	WBls:0000018
	The C. elegans life stage spanning 350-390min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. Emrbyo elongation started but have not formed comma shape yet. The shape of embryo looks like a lima bean. A stage right before comma embryo. Also called lima embryo or lima bean stage.		bean embryo Ce	WBls:0000016