WormMine

WS296

Intermine data mining platform for C. elegans and related nematodes

Anatomy Term :

Definition  Set two type of vulval muscle. Name  vm2
Primary Identifier  WBbt:0006918 Synonym  vulval muscle, type 2

4 Children

Definition Name Synonym Primary Identifier
Vulval muscle 2, of lineage M.vlpaapap. M.vlpaapap lineage name: M.vlpaapap WBbt:0004852
Vulval muscle 2, of lineage M.vrpaaapa. M.vrpaaapa lineage name: M.vrpaaapa WBbt:0004851
Vulval muscle 2, of lineage M.vrpaapap. M.vrpaapap lineage name: M.vrpaapap WBbt:0004848
Vulval muscle 2, of lineage M.vlpaaapa. M.vlpaaapa lineage name: M.vlpaaapa WBbt:0004855

1 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  Single-cell RNA-Seq cell group 143 expressed in: vm2 (vulval muscle). CellRanger, DecontX, Monocle3, Louvain algorithm. WBPaper00065623:143

10 Expression Patterns

Remark Reporter Gene Primary Identifier Pattern Subcellular Localization
    Expr10554 ser-4 is expressed in a subset of head and tail neurons. ser-4::GFP expression was seen in the serotonergic NSM neurons and in the vm2 egg-laying muscles. The only cell type that reliably coexpressed mod-1 and ser-4 reporter transgenes are AIB neurons.  
    Expr15937 We observed strong expression of kcnl-1 in neurons and muscles involved in egg-laying and defecation (vm1, vm2, uterine muscle, stomato-intestinal muscle, and anal depressor muscle). In addition, kcnl-1 was expressed in body-wall muscles, a few neurons in head and tail ganglia, ventral nerve cord motoneurons, and the PVD mechanosensory neuron.  
    Expr10991 elt-1 reporter gene expression was first seen around the 20-30 cell stage and was maintained during subsequent early embryogenesis in cells corresponding to hypodermal precursor cells. Just prior to morphogenesis, reporter gene expression could be seen in all the major hypodermal cell nuclei. During formation of the comma stage, embryo reporter gene expression declined in the dorsal and ventral hypodermis but remained high in the lateral seam cells. The seam-cell expression of the reporter gene continued throughout morphogenesis to the pretzel stage although at lower levels. In addition, at the threefold stage of development high levels of expression were seen in a group of cells adjacent to the pharynx in a position consistent with neuronal cells of the retrovesicular ganglion. During postembryonic development relatively low levels of expression were maintained in seam cells from the L1 to the adult stage as were high levels of ELT-1 in neuronal cells of the retrovesicular ganglion. ELT-1 expression was also clearly apparent in several different groups of neuronal cell bodies and axons; those of the ventral cord were the most prominent. Expression was also seen in several neurons in which the axon extended from the ventral cord and encircled the pharynx just in front of the posterior bulb.The reporter gene also showed postembryonic expression in sex-specific structures. In hermaphrodites, ELT-1 expression was seen in the vulval muscles (vm1 and vm2) and in males, in a subset of the lateral seam, the SET cells, that give rise to the sensory rays.  
    Expr1200166 Data from the TransgeneOme project  
    Expr10804 Transgenic animals carrying the lin-12::SL2::mCherry construct showed mCherry expression in a number of cell types including both the vm2 muscle cells and the vulval epithelial cells. Strikingly, no detectable lin-12 expression was observed in vm1 muscle cells.  
    Expr11588 arg-1::gfp is expressed in both type I vulval muscles (VM1s) and type II vulval muscles.  
    Expr10807 In wild-type animals, MADD-2 translational reporter was preferentially expressed and diffusely distributed in vm2 cells. madd-2 transcriptional fusion was also expressed in vm2 cells.  
    Expr10803 While high level of UNC-103E::GFP expression labels both the muscle arms and the vm cell bodies, low level of transgenic expression of UNC-103E::GFP with an integrated single-copy transgene showed that UNC-103E was dramatically enriched on vm2 muscle arms.  
    Expr13790 strong ser-4b GFP expression was observed in VulF and VulE primary and VulD secondary epithelial cells. The ser-4b promoter also drove weak GFP expression in the vm2 muscles in L4.7-9, and this was elevated in adults.  
    Expr10806 In wild-type animals, UNC-40 translational reporter was preferentially expressed in vm2 cells. UNC-40::GFP showed membrane-associated pattern and was enriched on vm2 muscle arms. unc-40 transcriptional fusion was also expressed in vm2 cells.  

0 Life Stages

1 Parents

Definition Name Synonym Primary Identifier
muscle associated with hermaphrodite vulva. vulval muscle   WBbt:0005821