1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00004215 | ptp-3 | C09D8.1 | Caenorhabditis elegans |
| Primary Identifier | Expr3649 | Subcellular Localization | PTP-3 was concentrated at the nerve ring and along the nerve cords in larval and adult animals and showed a punctate pattern. Along the nerve cord, PTP-3 was adjacent to but did not overlap UNC-49. Within the neurons, PTP-3 partially overlapped the SNT-1-containing domain but was concentrated at the edges of the SNT-1 staining. There was a precise colocalization of PTP-3 with SYD-2 and UNC-10. More specifically, a smaller punctum of PTP-3 was observed in or near the center of each of the larger SYD-2 puncta. These data indicate that PTP-3 is predominantly associated with the presynaptic density. To address whether PTP-3 localization was dependent on synaptic vesicles, the accumulation of SNT-1, PTP-3, and UNC-10 were analyzed in unc-104(e1265) kinesin mutants, which causes synaptic vesicles to be retained in cell bodies. PTP-3 and UNC-10 puncta showed colocalization in regions of the nerve cord lacking synaptic vesicles. Thus, like other presynaptic density components, PTP-3 appears to be trafficked to synapses independent of synaptic vesicles. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00004215 | ptp-3 | C09D8.1 | Caenorhabditis elegans |
