WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

Life Stage :

Definition  The life-stage that begins when a B. malayi individual is fully-developed and has reached maturity. Adult B. malayi (or at least adult females) can live for 10 years in a human host, and can outlive their rodent laboratory hosts; it is usual to state the chronological age of the nematodes in days or months post-infection, and occasionally post-patency (the production of first microfilariae). Primary Identifier  WBls:0000083
Public Name  Brugia adult
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0 Anatomy Terms

2 Contained In

Remark Definition Other Name Public Name Primary Identifier
  The nematode life-stage that begins when the organism is fully-developed and has reached maturity. nematode adult WBls:0000104
  A developemental life stage in a roundworm of the genus Brugia that occurs from egg hatching until death. Brugia postembryonic stage WBls:0000093

24 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_M120_vs_F120
  Transcripts that showed significantly increased expression in male B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_M120_vs_M30
  Transcripts that showed significantly decreased expression in male B. malayi 42 days after infecting gerbils, comparing to 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_M42_vs_M30
  Transcripts that showed significantly decreased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_F120_vs_F30
  Transcripts that showed significantly increased expression in male B. malayi 120 days after infecting gerbils, comparing to 42 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_M120_vs_M42
  Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_M120_vs_M30
  Transcripts that showed significantly increased expression in male B. malayi 30 days after infecting gerbils, comparing to female B. malayi 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_M30_vs_F30
  Transcripts that showed significantly increased expression in male B. malayi 42 days after infecting gerbils, comparing to female B. malayi 42 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_M42_vs_F42
  Transcripts that showed significantly increased expression in male B. malayi 42 days after infecting gerbils, comparing to 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_M42_vs_M30
  Transcripts that showed significantly decreased expression in female B. malayi 120 days after infecting gerbils, comparing to 42 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_F120_vs_F42
  Transcripts that showed significantly decreased expression in male B. malayi 30 days after infecting gerbils, comparing to female B. malayi 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_M30_vs_F30
  Transcripts that showed significantly increased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_F120_vs_F30
  Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to 42 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_M120_vs_M42
  Transcripts that showed significantly increased expression in female B. malayi 120 days after infecting gerbils, comparing to 42 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_F120_vs_F42
  Transcripts that showed significantly increased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_M120_vs_F120
  Transcripts that showed significantly increased expression in male B. malayi 30 days after infecting gerbils, comparing to L4 male B. malayi animals. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_M30_vs_L4
  Transcripts that showed significantly decreased expression in male B. malayi 30 days after infecting gerbils, comparing to L4 male B. malayi animals. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_M30_vs_L4
  Transcripts that showed significantly decreased expression in male B. malayi 42 days after infecting gerbils, comparing to female B. malayi 42 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_M42_vs_F42
  Transcripts that showed significantly increased expression in female B. malayi 30 days after infecting gerbils, comparing to L4 female B. malayi animals. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_F30_vs_L4
  Transcripts that showed significantly decreased expression in female B. malayi 30 days after infecting gerbils, comparing to L4 female B. malayi animals. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_F30_vs_L4
  Transcripts that showed significantly increased expression in female B. malayi 42 days after infecting gerbils, comparing to 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:upregulated_F42_vs_F30
  Proteins that were enriched in female animals. Criteria used for protein identification included: two or more peptide matches, MASCOT score > 60, and P < 0.05. WBPaper00041323:female-associated
  Proteins that were enriched in male animals. Criteria used for protein identification included: two or more peptide matches, MASCOT score > 60, and P < 0.05. WBPaper00041323:male-associated
  Transcripts that showed significantly decreased expression in female B. malayi 42 days after infecting gerbils, comparing to 30 days after infecting gerbils. EdgeR(v3.16.5), FDR < 0.05. WBPaper00051007:downregulated_F42_vs_F30

1 Expression Patterns

Remark Reporter Gene Primary Identifier Pattern Subcellular Localization
    Expr11949 B. malayi phy-1 is expressed in L1 (microfilaria), at all time points examined throughout L3 and L4 development, and in both adult sexes.  

0 Followed By

1 Preceded By

Remark Definition Other Name Public Name Primary Identifier
  The animals have a significant "prepatent" period in the host, where they have moulted to adults but not yet started producing eggs or sperm; this stage is usually-should be conditioned by days post infection, with day 26 to approximately day 60 being the "young adult" in most systems - but note that the speed of development is different in different host genotypes. Brugia young adult WBls:0000100

0 Sub Stages