WormMine: LifeStage WBls:0000100

• Definition: The animals have a significant "prepatent" period in the host, where they have moulted to adults but not yet started producing eggs or sperm; this stage is usually-should be conditioned by days post infection, with day 26 to approximately day 60 being the "young adult" in most systems - but note that the speed of development is different in different host genotypes.
• Primary Identifier: WBls:0000100
• Public Name: Brugia young adult

0 Anatomy Terms

2 Contained In

Remark	Definition	Other Name	Public Name	Primary Identifier
	Any Brugia developmental stage, including embryo, larva and adult stage.		Brugia life stage	WBls:0000091
	A developemental life stage in a roundworm of the genus Brugia that occurs from egg hatching until death.		Brugia postembryonic stage	WBls:0000093

3 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Proteins secreted by B.malayi at L3 larva stage, according to LC-MS-MS.	N.A.	WBPaper00050454:Secretome_protein
	Proteins that showed significantly increased expression in parasites exposed to 20-hydroxyecdysone.	An empirical filter of proteins with more than two peptides identified, a P value <0.05 and a greater than two-fold change of differential expression, was applied to the data. The Bonferroni correction was applied to correct the P value for the proteins analyzed.	WBPaper00049261:20-hydroxyecdysone_upregulated_protein
	Transcripts that showed significantly increased expression in parasites exposed to 20-hydroxyecdysone.	edgeR was used to analyze the data using the counts generated for the four samples with Cuffdiff.	WBPaper00049261:20-hydroxyecdysone_upregulated_RNAseq

0 Expression Patterns

1 Followed By

Remark	Definition	Other Name	Public Name	Primary Identifier
	The life-stage that begins when a B. malayi individual is fully-developed and has reached maturity. Adult B. malayi (or at least adult females) can live for 10 years in a human host, and can outlive their rodent laboratory hosts; it is usual to state the chronological age of the nematodes in days or months post-infection, and occasionally post-patency (the production of first microfilariae).		Brugia adult	WBls:0000083

1 Preceded By

Remark	Definition	Other Name	Public Name	Primary Identifier
	The fourth stage larva. Should be conditioned by days post infection; as moulting is not synchronous, some samples are defined as L3/L4, indicating a mix of individuals as late L3, moulting, and early L4.		Brugia L4	WBls:0000082

0 Sub Stages