WormMine

WS294

Intermine data mining platform for C. elegans and related nematodes

Expression Pattern :

Pattern  In early embryos, MES-3 protein is present in the nuclei of all cells. As embryogenesis progresses, staining gradually diminishes in somatic cells. In late embryos and L1 larvae, MES-3 is detectable in some somatic cells but is most prominent in Z2 and Z3, the primordial germ cells. The nuclear staining of MES-3 is reduced below detection in any of the four nonconditional alleles of mes-3. In wild type adults, MES-3 is most prominent in germline nuclei and is occasionally barely detectable in intestinal nuclei. In the germline, it is present at low levels in distal mitotic nuclei, undetectable in the pachytene region of the distal arm, and present at elevated levels in the proximal meiotic region and in oocytes. Primary Identifier  Expr1736
Remark  early embryo (author) = blastula embryo (curator) --wjc. Subcellular Localization  MES-3 is localized predominantly in nuclei. The immunolocalization pattern of MES-3 was analyzed in embryos, using confocal microscopy. Cells at different stages of mitosis were stained by affinity-purified anti-MES-3 antibody and anti-penta-acetylated H4 antibody to visualize chromosomes. During interphase and prometaphase, when condensed chromosomes are clearly visible in nuclei, MES-3 protein is not obviously concentrated on chromosomes; instead it appears evenly distributed in the nucleoplasm. During metaphase and early anaphase, when nuclear envelopes are broken down, some MES-3 protein is detectably associated with chromosomes.
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58 Anatomy Terms

Definition Name Synonym Primary Identifier
cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes. germ line germline WBbt:0005784
embryonic cell MSa   WBbt:0006086
embryonic cell MSp   WBbt:0005912
Embryonic founder cell MS lineage name: P0.paa WBbt:0004458
embryonic cell ABalp   WBbt:0005865
Embryonic founder cell E lineage name: P0.pap WBbt:0004804
embryonic cell ABarp   WBbt:0006653
embryonic cell ABprp   WBbt:0006451
embryonic cell Ep   WBbt:0006612
embryonic cell ABplp   WBbt:0006279
Single cell zygote P0 lineage name: Z WBbt:0004422
embryonic cell ABarpp   WBbt:0006046
embryonic cell ABalpp   WBbt:0006486
embryonic cell MSpa   WBbt:0006142
embryonic founder cell Psub3 lineage name: P0.ppp WBbt:0006875
embryonic cell Cpa   WBbt:0006281
embryonic founder cell Psub1 lineage name: P0.p WBbt:0006874
embryonic founder cell Psub2 lineage name: P0.pp WBbt:0006873
Embryonic founder cell D lineage name: P0.pppa WBbt:0004873
embryonic cell MSpp   WBbt:0006255
Embryonic founder cell of germ line Psub4 lineage name: P0.pppp WBbt:0004421
embryonic cell EMS   WBbt:0006876
embryonic cell ABplap   WBbt:0006096
embryonic cell ABalap   WBbt:0006101
embryonic cell ABala   WBbt:0006707
embryonic cell ABarap   WBbt:0005903
embryonic cell ABal   WBbt:0006110
embryonic cell ABprpa   WBbt:0005915
embryonic cell Cp   WBbt:0006117
embryonic cell ABa   WBbt:0005906

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003221 mes-3 F54C1.3 Caenorhabditis elegans

3 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch. L1 larva Ce WBls:0000024
  The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching. embryo Ce WBls:0000003
  The stage after an hermaphrodite animal is fully-developed and reaches maturity. adult hermaphrodite Ce WBls:0000057