| Pattern | hlh-2 appears to be transcribed in both Z1.ppp and Z4.aaa, even though HLH-2 protein is never detected in more than the presumptive AC (see Expr1470). HLH-2 does not accumulate in two other cells in which hlh-2 is transcribed, Z1.ppa and Z4.aap, the sisters of Z1.ppp and Z4.aaa. These cells have the potential to become ACs, but in wild-type hermaphrodites, invariably become VUs. | Primary Identifier | Expr2824 |
| Remark | A translational reporter, HA-HLH-2, under the control of identical regulatory sequences as hlh-2::lacZ was examed for comparison. Transgenic lines were generated at the same concentrations and in a smg-1 background, as for hlh-2 lacZ. HA-HLH-2 showed the same pattern of accumulation as endogenous HLH-2 protein. There were two categories of animals, those with accumulation in neither Z1.ppp nor Z4.aaa (younger animals), and those with accumulation in one cell (older animals). The similar patterns of accumulation of HA-HLH-2 and endogenous HLH-2 indicate that the difference in expression between the hlh-2::lacZ transcriptional reporter and the endogenous HLH-2 protein is real. The observation that the transcriptional reporter is expressed in the presumptive VU, in which HLH-2 protein accumulation is not detected, suggests that HLH-2 protein accumulation may be post-transcriptionally regulated. No detailed description on expression patterns in other tissues. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| post-embryonic cell of pedigree Z4.aap | Z4.aap | VU | WBbt:0007707 |
| post-embryonic cell of pedigree Z4.aaa | Z4.aaa | WBbt:0007688 | |
| post-embryonic cell of pedigree Z1.ppp | Z1.ppp | WBbt:0007667 | |
| post-embryonic cell of pedigree Z1.ppa | Z1.ppa | WBbt:0007628 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00001949 | hlh-2 | M05B5.5 | Caenorhabditis elegans |
