Genomics
2 Transcripts
| Class | WormMine ID | Sequence Name | Length (nt) | Chromosome Location |
|---|---|---|---|---|
| MRNA | Transcript:M05B5.5a.1 | M05B5.5a.1 |
1665
 |
I: 7190788-7193920 |
| NcPrimaryTranscript | Transcript:M05B5.5b | M05B5.5b |
1156
|
I: 7191240-7193907 |
Other
1 CDSs
| WormMine ID | Sequence Name | Length (nt) | Chromosome Location |
|---|---|---|---|
| CDS:M05B5.5a | M05B5.5a |
1200
|
I: 7191240-7191362 |
80 RNAi Result
33 Allele
| Public Name |
|---|
| gk962858 |
| gk962706 |
| gk963902 |
| n5053 |
| h12730 |
| ar614 |
| gk604735 |
| gk638016 |
| gk350103 |
| gk815772 |
| gk789903 |
| gk743296 |
| WBVar02049365 |
| n5287 |
| ar623 |
| bx108 |
| bx115 |
| tm1768 |
| gk862366 |
| gk562810 |
| gk114488 |
| gk513031 |
| gk114489 |
| gk648028 |
| gk920102 |
| gk544973 |
| gk575502 |
| gk552499 |
| hu82 |
| gk542947 |
1 Chromosome Location
|
Feature . Primary Identifier |
Start | End | Strand |
|---|---|---|---|
| WBGene00001949 | 7190788 | 7193920 | -1 |
4 Data Sets
| Name | URL |
|---|---|
| WormBaseAcedbConverter | |
| GO Annotation data set | |
| C. elegans genomic annotations (GFF3 Gene) | |
| Panther orthologue and paralogue predictions |
1 Downstream Intergenic Region
| WormBase ID | Name | Sequence Name | Length (nt) | Chromosome Location | Organism |
|---|---|---|---|---|---|
| intergenic_region_chrI_7190582..7190787 | 206 | I: 7190582-7190787 | Caenorhabditis elegans |
200 Expression Clusters
| Regulated By Treatment | Description | Algorithm | Primary Identifier |
|---|---|---|---|
| Genes with expression altered >= 3-fold in dpy-10(e128) mutants. | Data across the wild type series was analyzed using the Significance analysis of Microarrays (SAM) algorithm (to calculate the False Discovery Rate (FDR)). | WBPaper00035873:dpy-10_regulated | |
| Transcripts that showed significantly increased expression in L1 neural cells comparing to in adult neural cells. | DESeq2 (v1.18.1) fold change > 2, P-adj<0.05, using BenjaminiHochberg correction. | WBPaper00060811:L1_vs_adult_upregulated_neural | |
| Transcripts of coding genes that showed significantly decreased expression in muscle. | DESeq2 (version 1.24.0). Transcripts with a false-discovery rate adjusted p-value less than 0.05 were considered significantly differentially expressed. | WBPaper00062325:muscle_depleted_coding-RNA | |
| Transcripts expressed in neuronal cells, by analyzingfluorescence-activated cell sorted (FACS) neurons. | DESeq. False discovry rate (FDR) < 0.1. | WBPaper00048988:neuron_expressed | |
| adult vs dauer larva | Transcripts that showed differential expression in adult vs dauer lava in N2 animals at 20C. | N.A. | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| Osmotic stress | Transcripts that showed significantly altered expression with 500 mM salt (NaCl) vs 100 mM salt when food was present | DESeq(version 1.10.1), FDR < 0.05. | WBPaper00050726:OsmoticStress_regulated_Food |
| Maternal class (M): genes that are called present in at least one of the three PC6 replicates. | A modified Welch F statistic was used for ANOVA. For each gene, regressed error estimates were substituted for observed error estimates. The substitution is justified by the lack of consistency among the most and least variable genes at each time point. Regressed error estimates were abundance-dependent pooled error estimates that represented a median error estimate from a window of genes of similar abundance to the gene of interest. A randomization test was used to compute the probability Pg of the observed F statistic for gene g under the null hypothesis that developmental time had no effect on expression. P-values were not corrected for multiple testing. | [cgc5767]:expression_class_M | |
| Transcripts that showed significantly decreased expression in day 3 adult hermaphrodite comparing to in L4 larva daf-16(mu86);glp-1(e2141) animals. | Fold change > 2, FDR < 0.05 | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) | |
| Transcripts that showed significantly decreased expression in day 3 adult hermaphrodite comparing to in L4 larva glp-1(e2141) animals. | Fold change > 2, FDR < 0.05 | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) | |
| Bacteria diet: Escherichia coli HB101. Fed for 30 generations. | Transcripts that showed significantly decreased expression after fed by bacteria E. coli HB101 for 30 generations comparing to animals fed by E. coli OP50. | DESeq2 fold change > 2, p-value < 0.01. | WBPaper00061007:HB101_downregulated |
| Bacteria diet: Sphingomonas aquatilis Yellow. Fed for 30 generations. | Transcripts that showed significantly decreased expression after fed by bacteria Sphingomonas aquatilis (Yellow) for 30 generations comparing to animals fed by E. coli OP50. | DESeq2 fold change > 2, p-value < 0.01. | WBPaper00061007:S.aquatilis_downregulated |
| Bacteria infection: Bacillus thuringiensis | mRNAs that showed significantly decreased expression after pathogenic bacteria Bacillus thuringiensis infections comparing to non pathogenic BT (BT247(1 to 10 mix) vs BT407 12h), according to RNAseq. | Cuffdiff, ajusted p-value < 0.01. | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| Bacteria infection: Bacillus thuringiensis | mRNAs that showed significantly decreased expression after pathogenic bacteria Bacillus thuringiensis infections comparing to non pathogenic BT (BT247(1 to 2 mix) vs BT407 6h), according to RNAseq. | Cuffdiff, ajusted p-value < 0.01. | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| Bacteria infection: Bacillus thuringiensis | mRNAs that showed significantly decreased expression after pathogenic bacteria Bacillus thuringiensis infections comparing to non pathogenic BT (BT247(1 to 2 mix) vs BT407 12h), according to RNAseq. | Cuffdiff, ajusted p-value < 0.01. | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| Transcripts that showed significantly increased expression in hrde-1(tm1200) animals, comparing to in N2, after growing at 25C for five generations (late generation). | CuffDiff2 | WBPaper00051265:F4_hrde-1(tm1200)_upregulated | |
| Transcripts that showed significantly increased expression in aak-1(tm1944);aak-2(ok524) animals comparing to in N2. | DEseq 1.18.0, adjusted p-value < 0.05. | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated | |
| Transcripts that showed significantly increased expression in animal with pgph-2 overepxreesion [pgph-2p-pgph-2; myo-2p-mcherry] in glucose excess condition. | Genes with anadjusted P-value <= 0.05 found by DESeq2 were assigned as differentially expressed. | WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose | |
| 25C vs. 20C | Transcripts that showed significantly increased expression in 1-day post L4 adult hermaphrodite N2 grown at 25C, comparing to in N2 animals grown at 20C. | CuffDiff, fold change > 2. | WBPaper00065096:25C_vs_20C_upregulated |
| Transcripts that showed significantly increased expression in 10-days post L4 adult hermaphrodite N2 grown at 20C, comparing to in 1-day post L4 adult hermaphrodite N2 animals grown at 20C. | CuffDiff, fold change > 2. | WBPaper00065096:Day10_vs_Day1_upregulated | |
| Transcripts that showed significantly increased expression in xrep-4(lax137). | DESeq2. Genes were selected if their p value < 0.01. | WBPaper00066062:xrep-4(lax137)_upregulated | |
| Transcripts that showed significantly decreased expression in tetraploid N2 comparing to diploid N2 animals at L4 larva stage. | DESeq2 R package (1.20.0), fold change > 2, and FDR < 0.05. | WBPaper00066110:tetraploid_vs_diploid_downregulated | |
| Transcripts that showed significantly increased expression in BAT525 [hmg-3 (tm2539) / dpy-5(e61) unc-13(e1091) I.] comparing to in N2 at 1-day post L4 adult hermaphrodite stage. | DESeq 2, fold change > 4, adjusted p-value < 0.05. | WBPaper00055013:hmg-3(bar24)_upregulated | |
| Transcripts that showed significantly increased expression in pry-1(mu38) animals comparing to in N2 at L1 larva stage. | DESeq, FDR < 0.05 | WBPaper00055626:pry-1(mu38)_upregulated | |
| Starvation | Transcripts that showed significantly altered expression by starvation with 100 mM salt (NaCl) | DESeq(version 1.10.1), FDR < 0.05. | WBPaper00050726:starvation_regulated_LowSalt |
| Transcripts that showed significantly decreased expression in the neurons of bcat-1(RNAi) animals at 5-days post L4 adult hermaphrodite stage, comparing to animals injected with empty vector. | DESeq2. FDR < 0.05. | WBPaper00060459:bcat-1(RNAi)_downregulated | |
| Transcripts that showed significantly decreased expression in nhl-2(ok818) comparing to in N2 at 25C. | EdgeR, FDR < 0.05, fold change < 0.5. | WBPaper00055971:nhl-2(ok818)_25C_upregulated | |
| Transcripts that showed decreased expression in hlh-11(ko1) knockout strain comparing to in wild type background. | DESeq2, FDR < 0.05 | WBPaper00060683:hlh-11(ko1)_downregulated | |
| Transcripts that showed significantly increased expression in animals lacking P granules by RNAi experiments targeting pgl-1, pgl-3, glh-1 and glh-4, and unc-119-GFP(+), comparing to in control animals, at 2-day post L4 adult hermaphrodite stage. | DESeq2, Benjamini-Hochberg multiple hypothesis corrected p-value < 0.05 and fold change > 2. | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult | |
| Bacteria infection: Enterococcus faecalis OG1RF. Exposure for 16 hours. | Transcripts that showed significantly decreased expression in hpx-2(dg047) after animals were exposed to E. faecalis OG1RF for 16 hours comparing to exposure to E. Coli OP50. | Cuffcompare and Cuffdiff | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| Genes found to be regulated by low-copy overexpression of sir-2.1 with p < 0.014. | N.A. | WBPaper00026929:sir-2.1_overexpression_regulated |
20 Expression Patterns
| Remark | Reporter Gene | Primary Identifier | Pattern | Subcellular Localization |
|---|---|---|---|---|
| Expr4414 | In wild type animals, detectable expression of hlh-2 was limited to the bend and proximal region of the gonad | |||
| Expr1031134 | Tiling arrays expression graphs | |||
| Sequence Genbank accession numbers cDNA = U13614; genDNA = U30248 Vertebrate Homologs: Human and mouse protein(s) E12/E47. Invertebrate Homologs: Drosophila protein "Daughterless". Vertebrate E12 acts with MyoD. early embryonic expression profile would be consistant with a role of CeE12/Da in dosage comp. analogous to Daughterless in Dros.mel. but not evidence for it. Later embryonic expression suggests CeE12/Da is important for neurogenesis, probably a pairing partner for the acheate-scute homologs in the worm. This would be similar function to its role in vertebrates and Dros.mel.. CeE12 does not appear to be in body wall muscle cells therefore not a pairing partner for CeMyoD; this result is in constrast to vertebrate functions. life_stage summary : postembryonic | Expr57 | Antibody staining: nuclear stained blastomeres from at least 2 cell stage on. All blastomeres stain up to about the 200 cell stage. Pattern then becomes dynamic. Dorsal blastomere expression turns off, leaving strong expression in head, ventral cord region, and tail at comma stage. As embryogenesis continues, expression fades in most cells so that by hatching, only ~12 cells positive for expression in head and ~6 cells in tail (all presumptive neurons). Post-embryonic staining unknown. lacZ expression: 1 construct in 3 independant lines shows onset of expression in comma stage embryos in a few presumptive neuronal precursors in the head. In later stage embryos expression is in the head, ventral half and tail of embryos. This expression co-localizes with areas of neurogenesis. Post-embryonic expression in occasional neurons in head, tail, or midsection. | ||
| CeE/Da = hlh-2 in the article. | Expr1470 | CeE/DA can first be detected in both nuclei of 2-cell embryos. Staining persists apparently in all nuclei of the early embryo for the first 150-200 minutes of development (100-200 cells). By 270 minutes of development (approx. 350 cells) a dramatic change in antibody staining has occurred in which persistent staining is seen in progressively fewer blastomeres. Most, but not all, blastomeres that initially retain CeE/DA antibody staining at this stage are neurons or their immediate precursors. There are a few neuronal precursors that are located away from the neuronal clusters in the embryo (for example the postembryonic neuroblast W), for which antibody staining was not detected. Therefore, although persistent antibody staining is largely restricted to neurons or their precursors, not every such cell is antibody-positive. CeE/DA-antibody staining is transient for the majority of these cells, with the staining progressively lost as differentiation and morphogenesis occur. This is most clearly evident at the 1.5-fold stage of embryogenesis, in which a lateral view of the embryo shows staining in the head, ventral nerve cord and tail. As the embryo begins elongating, the level of CeE/DA-antibody staining decreases in these cells. Note that most of these cells are postmitotic. Although the majority of cells lose CeE/DA-antibody staining during the later half of embryogenesis, a small percentage of cells remain antibody-positive through the remainder of embryogenesis and after hatching. There are 14 of these continually staining cells in the head and seven more in the tail region. Of the 14 head cells, 5 are pharyngeal. The pharyngeal nuclei have been identified, as two pharyngeal muscle nuclei (pm5L and R) and three pharyngeal gland cell nuclei (g1P, g2L and R). The remaining nine CeE/DA antibody-positive cells in the head are outside of the pharynx and are located in the neuronal cluster between the nerve ring and the posterior pharyngeal bulb. There are four bilateral pairs of stained nuclei and one positive nucleus lying along the ventral mid-line. Using hlh-2::GFP reporter strains and DiI staining, three of the bilateral pairs of neurons have been identified as ADL (L and R) and ASH (L and R) and RIC (L and R). The large number of neurons in this area makes it difficult to identify unambiguously each of the remaining three CeE/DA antibody-positive cells. The seven tail cells with nuclei that remain CeE/DA antibody-positive throughout embryonic development include the two Q neuroblasts and five cells were tentatively identified as DVA (an interneuron), the bilateral pair of intestinal muscle cells, the anal depressor muscle and the anal sphincter muscle. The two intestinal and two anal muscle cells are postmitotic and are non-striated muscles. CeE/Da is not detected in bodywall muscles. In addition to the 21 cells that are CeE/DA antibody-positive at hatching, there are several additional cells detected immunologically during subsequent development. One prominent set of cells that becomes CeE/DA antibody-positive during the L3 stage are the 16 developing vulval and uterine muscle cells (non-striated). These nuclei remain antibody-positive in the mature vulva, although staining intensity appears to decrease. Another prominent pair of postembryonic, CeE/DA antibody-positive nuclei are the distal tip cells (DTC). The DTC nuclei are CeE/DA antibody-positive from the start of gonad elongation in larval development and remain positive in adulthood. Very faint antibody staining can also be detected in the syncytial gonad. | At all developmental stages, CeE/DA antibody staining is nuclear (except in the germline). | |
| Expr14321 | Using a fosmid-based reporter of hlh- 2/Da expression, we found that ADL and ASH expression of hlh-2/Da, as well as expression in a few other head and tail neurons, is maintained throughout all larval stages into adulthood | |||
| Expr14592 | hlh-2, hlh-3, and hlh-4 are all expressed in ADL neurons but in a temporal specific manner. While hlh-2 is expressed in ADL throughout development from the embryo to the adult consistent with previous reports, we find that both hlh-3 and hlh-4 are transiently expressed in ADL. Expression of hlh-3 in ADL is observed in the late embryo before hatching, but not in L2 larvae or in adults. However, it remains possible that hlh-3 is very lowly expressed in ADL. In contrast, we observed that hlh-4 is expressed in ADL neurons in L1 larvae and in adults, but we did not observe hlh-4 expression in ADL in late-staged embryos before hatching. We observed that similar to hlh-4, hlh-10 is expressed in ADL neurons in larvae and adults, again opposite to the expression of hlh-3 observed in ADL. Thus, while hlh-2 is expressed in ADL throughout development, hlh-3 and hlh-4 may be transiently expressed in ADL. | |||
| Picture: Fig S5A, S5B. | Expr8711 | In hermaphrodites, this reporter was expressed soon after the hDTC was born and expression persisted throughout the life of the hDTC. In males, hlh-2::GFP expression was not seen in the SGPs (Z1/Z4), but it was expressed in mDTCs after the first SGP division. Moreover, expression persisted throughout development and in adults. Therefore, hlh-2 expression is likely not sexually dimorphic. | ||
| Expr1021575 | Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/levin2012 | |||
| Expr9633 | In the somatic gonad, GFP::HLH-2 was expressed at low levels in the Z1/Z4 somatic gonadal precursor cells at the L1 stage. During the time of the AC/VU decision, GFP::HLH-2 was expressed in both pre-AC and pre-VU cells, and after the AC/VU decision, GFP::HLH-2 was reduced in the VU and its descendants. GFP::HLH-2 persisted in the AC through the time of invasion. | |||
| Picture: Fig. 4G to 4I. | [hlh-2p::hlh-2::gfp] translational fusion. Authors generated a translational hlh-2::gfp fusion gene by an in-frame insertion of a gfp-coding sequence to the 3' end of the hlh-2-coding sequence flanked by the 18.7 kb 5' upstream and 10.6 kb 3' downstream genomic sequence. Authors integrated this hlh-2::gfp transgene into the C. elegans genome and found that hlh-2::gfp rescued the MI transformation as well as the embryonic lethality of hlh-2(n5053) mutants, indicating that hlh-2::gfp is functional. | Expr9153 | Authors observed developing embryos carrying hlh-2::gfp and found that HLH-2::GFP was localized asymmetrically: HLH-2::GFP was detectable in the MI mother cell but not in the e3D mother cell. | |
| Expr3090 | An hlh-2::lacZ transcriptional reporter appears to be expressed in a similar pattern to HLH-2 protein during the L1 stage. HLH-2 does not accumulate detectably in any cell of the gonad until Z1 and Z4 have undergone two rounds of division, near the end of the L1 stage. HLH-2 was consistently observed in the DTCs (Z1.aa and Z4.pp) and in the presumptive AC and mature AC. HLH-2 was also weakly and inconsistently present in Z1.pp and Z4.aa (the parents of Z1.ppp and Z4.aaa), as well as their sisters, Z1.pa and Z4.ap. | While HLH-2 accumulation in the DTCs is nuclear, as expected for a transcription factor, HLH-2 is detectable in the cytoplasm as well as the nucleus of other gonadal cells. | ||
| Expr13298 | HLH-2::GFP was expressed in the I4 neuron shortly after its generation but was absent from its sister cell, pm5. Also like HLH-3::GFP (Expr13297), HLH-2::GFP was broadly expressed in early embryos but was not detectable in most neurons, including I4 in newly hatched L1s, suggesting that hlh-2 most likely functions in early embryos to promote I4 specification. | |||
| Expr12416 | The level of HLH-2 protein is similar between the NBSMDD/AIY -ABplpapaaa, ABprpapaaa-neuroblast and its posterior sister the NBSIAD/SIBV -ABplpapaap, ABprpapaap- neuroblast. | |||
| Expr12521 | 'hlh-2prox', an element from the hlh- 2 5' flanking region, is necessary and sufficient to promote transcription only in the four alpha and beta cells of the developing ventral uterus. | |||
| Lineage expression: Rn descandents. Lineage expression: SM lineage. | Expr2435 | HLH-2 was not detectable in the seam cells that give rise to the ray precursor cells before the mid-L3 stage. Expression in the seam was first apparent in each of the nine Rn cells; upon the division of these cells, HLH-2 could be detected only in the anterior daughter, the ray neuroblast. Later expression of HLH-2 in ray sublineage cells(probably both Rn.aa and Rn.ap) was also observed, but unable to unambiguously identify individual cells because of the higher levels of HLH-2 expression directly underlying the hypodermis, in the male sex muscle cell lineages. | ||
| A translational reporter, HA-HLH-2, under the control of identical regulatory sequences as hlh-2::lacZ was examed for comparison. Transgenic lines were generated at the same concentrations and in a smg-1 background, as for hlh-2 lacZ. HA-HLH-2 showed the same pattern of accumulation as endogenous HLH-2 protein. There were two categories of animals, those with accumulation in neither Z1.ppp nor Z4.aaa (younger animals), and those with accumulation in one cell (older animals). The similar patterns of accumulation of HA-HLH-2 and endogenous HLH-2 indicate that the difference in expression between the hlh-2::lacZ transcriptional reporter and the endogenous HLH-2 protein is real. The observation that the transcriptional reporter is expressed in the presumptive VU, in which HLH-2 protein accumulation is not detected, suggests that HLH-2 protein accumulation may be post-transcriptionally regulated. No detailed description on expression patterns in other tissues. | Expr2824 | hlh-2 appears to be transcribed in both Z1.ppp and Z4.aaa, even though HLH-2 protein is never detected in more than the presumptive AC (see Expr1470). HLH-2 does not accumulate in two other cells in which hlh-2 is transcribed, Z1.ppa and Z4.aap, the sisters of Z1.ppp and Z4.aaa. These cells have the potential to become ACs, but in wild-type hermaphrodites, invariably become VUs. | ||
| Expr2030743 | Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans). | |||
| Expr2012504 | Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans). | |||
| Expr1154625 | Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015 | |||
| Expr16026 | GFP::HLH-2 expression was higher in alpha cells, which are fated to be ACs. |
56 GO Annotation
| Annotation Extension | Qualifier |
|---|---|
| has_input(WB:WBGene00005441),occurs_in(WBbt:0005661),part_of(GO:0032094) | enables |
| enables | |
| contributes_to | |
| enables | |
| enables | |
| enables | |
| enables | |
| enables | |
| enables | |
| enables | |
| enables | |
| enables | |
| involved_in | |
| involved_in | |
| involved_in | |
| involved_in | |
| enables | |
| enables | |
| enables | |
| enables | |
| involved_in | |
| involved_in | |
| involved_in | |
| has_input(WB:WBGene00002246) | involved_in |
| involved_in | |
| involved_in | |
| involved_in | |
| involved_in | |
| involved_in | |
| involved_in |
13 Homologues
| Type |
|---|
| orthologue |
| orthologue |
| orthologue |
| orthologue |
| least diverged orthologue |
| least diverged orthologue |
| least diverged orthologue |
| orthologue |
| least diverged orthologue |
| orthologue |
| orthologue |
| orthologue |
| least diverged orthologue |
56 Ontology Annotations
| Annotation Extension | Qualifier |
|---|---|
| has_input(WB:WBGene00005441),occurs_in(WBbt:0005661),part_of(GO:0032094) | enables |
| enables | |
| contributes_to | |
| enables | |
| enables | |
| enables | |
| enables | |
| enables | |
| enables | |
| enables | |
| enables | |
| enables | |
| involved_in | |
| involved_in | |
| involved_in | |
| involved_in | |
| enables | |
| enables | |
| enables | |
| enables | |
| involved_in | |
| involved_in | |
| involved_in | |
| has_input(WB:WBGene00002246) | involved_in |
| involved_in | |
| involved_in | |
| involved_in | |
| involved_in | |
| involved_in | |
| involved_in |
1 Regulates Expr Cluster
| Regulated By Treatment | Description | Algorithm | Primary Identifier |
|---|---|---|---|
| Transcripts that showed significant change of expression in hlh-2(RNAi) comparing to N2 animals injected with vector control. | Both edgeR FDR and DESeq2 FDR < 0.05 required for a gene to be considered differentially expressed. | WBPaper00059477:hlh-2(RNAi)_regulated |