WormMine: RNAi WBRNAi00103054

• WormBase ID: WBRNAi00103054
• Genotype: unc-119(ed4)III; hhIs64 [unc-119(?); sur-5::UbV-GFP]III (strain listed as PP563).
• Phenotype Remark: Knockdown of oxi-1 by RNAi only minimally affected the degradation of UbV-GFP under basal conditions. However exposing worms to low doses of the oxidative stress-inducing agent paraquat resulted in stabilization of UbV-GFP (loss of degradation).
• Remark: Authors engineered a ubiquitin fusion degradation(UFD) substrate in which a noncleavable ubiquitin is N-terminally fused to GFP (UbV-GFP) and expressed under the control of the sur-5 promoter to monitor protein degradation in vivo.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00003898	oxi-1	Y39A1C.2	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Y39A1C.2	Y39A1C.2	3201	III: 10858313-10858458

0 Laboratories

2 Phenotype

Identifier	Name	Description
WBPhenotype:0001645	protein degradation variant	Variations in the chemical reactions and pathways resulting in the directed breakdown of a protein (via the destruction of its native, active configuration) compared to control.
WBPhenotype:0000460	paraquat response variant	Animals exhibit variations in their response to paraquat compared to that observed in control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00041777

0 Strain