WormMine: RNAi WBRNAi00107714

• WormBase ID: WBRNAi00107714
• Phenotype Remark: "During AC invasion, the c-fos transcription factor ortholog fos-1 promotes expression the zinc metalloprotease zmp-1, the protocadherin cdh-3, the zinc finger protein egl-43, the hemicentin extracellular matrix protein gene him-4, and lamillopodin/mig-10; the activities of these genes induce the AC to form ventrally directed protrusions that breach the basement membrane (Fig 6A; Sherwood et_al, 2005; Hwang et_al 2007; Wang et_al, 2014). RNAi against the AC invasion genes resulted in defects in utse development (Table 2E; Fig 6B-D; F-H; J-L; N-P; R-T; V-X), supporting our hypothesis that genes involved in AC protrusion formation also affect utse development... As it is necessary for mediating cell-cell interactions, and is expressed ventral to the utse (Fig 6Q) it is not surprising that lack of hemicentin in him-4(RNAi) also results in utse defects even though him-4 is not expressed in the utse (Fig 6Q)."
• Remark: (Table 2, Figure 6) him-4 RNAi

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00001863	him-4	F15G9.4	Caenorhabditis elegans

5 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:F15G9.4d	F15G9.4d	11889	X: 9717626-9717878
CDS:F15G9.4a	F15G9.4a	15528	X: 9717626-9717878
CDS:F15G9.4e	F15G9.4e	15303	X: 9718417-9718480
CDS:F15G9.4f	F15G9.4f	15234	X: 9718417-9718480
CDS:F15G9.4b	F15G9.4b	15597	X: 9717626-9717878

0 Laboratories

1 Phenotype

Identifier	Name	Description
WBPhenotype:0000529	cell development variant	Any variation in the progression of a cell from when it is first formed to when it becomes a mature structure when compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00045833

0 Strain