WormMine: RNAi WBRNAi00106285

• WormBase ID: WBRNAi00106285
• Genotype: unc-45(e286)
• Phenotype Remark: "To re-examine the role of these co-chaperones in muscle function, wild-type and unc-45(e286) animals were treated with RNAi for known Hsp90 co-chaperones (Haslbeck et al., 2012, 2013) (17 genes; Table 1) and changes in motility were monitored. The detection threshold was increased in this secondary screen and animals were scored for any change in motility. Of the genes examined, only down-regulation of C-elegans p23 (Cep23; ZC395.10) resulted in motility defects of unc-45(e286) mutant animals but not wild-type animals. 39 11.3% of the unc-45(e286) mutant animals examined were motile (Figures 4A,B and data not shown). Although Cep23 modulated unc-45(ts) motility to a lesser extent than CeHop or CeAha1 (Figures 2C, 4B), Cep23 effect on unc-45(ts) motility was highly significant (p < 0.005)."
• Remark: (Figure 4) ZC395.10/Cep23 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation. If Ahringer clone not available, Vidal laboratory clone used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00022599	daf-41	ZC395.10	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:ZC395.10	ZC395.10	528	III: 5273989-5274047

0 Laboratories

1 Phenotype

Identifier	Name	Description
WBPhenotype:0000644	paralyzed	Animals do not move and are not responsive to external mechanical stimulation.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00046852

0 Strain