WormMine: RNAi WBRNAi00091343

• WormBase ID: WBRNAi00091343
• Phenotype Remark: lgg-1/lgg-2 RNAi prevents the autophagic degradation of sperm-derived "membranous organelles" (MOs) and mitochondria and thus results in persistence of these organelles in embryos as late as the 120-cell stage. The presence of paternal, sperm-derived mitochondria was confirmed by embryo PCR on mitochondrial DNA specific to the sperm.
• Remark: (Figure 3, Text) lgg-1/lgg-2 RNAi. Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

2 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00002980	lgg-1	C32D5.9	Caenorhabditis elegans
WBGene00002981	lgg-2	ZK593.6	Caenorhabditis elegans

3 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:ZK593.6a	ZK593.6a	429	IV: 10934764-10934917
CDS:ZK593.6b	ZK593.6b	225	IV: 10934764-10934917
CDS:C32D5.9	C32D5.9	372	II: 6347263-6347346

1 Laboratories

Primary Identifier
VIG

3 Phenotype

Identifier	Name	Description
WBPhenotype:0000117	L1 lethal	Animals die at the L1 stage of the life cycle.
WBPhenotype:0001020	embryonic lethal late emb	Animals die during the final stages of embryogenesis. In C. elegans, this lethality refers to death during the last (3-fold) stage of embryogenesis, which normally occurs 620-800 min after the first cleavage at 20C, the stage after elongation.
WBPhenotype:0000736	autophagy variant	Animals exhibit variations in the process by which their cells digest parts of their own cytoplasm, compared to control.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00040387

0 Strain