Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die.
The animal displays defects in any step of the ventral enclosure process resulting an embryo that is not enclosed and or with interior cells protruding out of the embryo.
Variations in the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control.