WormMine: RNAi WBRNAi00078095

• WormBase ID: WBRNAi00078095
• Genotype: mig-6(ev701)/eT1
• Phenotype Remark: Suppression of the phase 2 DTC defect was partial when RNAi was used to reduce EMB-9/collagen IV in mig-6(ev701) heterozygotes. Loss of precise DTC guidance along the DV axis of the lateral epidermis during the phase 2 migration is the phenotype of mig-6(ev701) heterozygous animals. Authors call this the class-s (class-short) defect as it is caused by disruption of the mig-6 short isoform. Migration is not slow as seen with the disruption of the long isoform. In wildtype, phase 1 migration comprises a longitudinal migration in opposite directions away from the mid-body using the ventral body muscle basement membrane as a substratum for migration. During phase 2, the DTCs turn and migrate across the lateral epidermal basement membrane towards the dorsal body wall muscles.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00001263	emb-9	K04H4.1	Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:K04H4.1a	K04H4.1a	5280	III: 9337163-9337258
CDS:K04H4.1b	K04H4.1b	4509	III: 9337163-9337258

1 Laboratories

Primary Identifier
NW

1 Phenotype

Identifier	Name	Description
WBPhenotype:0000195	distal tip cell migration variant	Variations in the migration pattern of distal tip cells compared to control animals. In C. elegans, DTCs located on the anterior and posterior ends of the gonad primordium typically migrate in a symmetrical U-shaped pattern.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00033006

0 Strain