WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00102843 Phenotype Remark  nhr-49(RNAi) worms showed increased fat storage under Oil Red O staining (Fig. 6A and B, Supplemental Fig. 5). They showed a marked increase in body size and significantly lower expression of mitochondrial beta-oxidation genes, ech-1 (encodes a mitochondrial beta-oxidation trifunctional enzyme), cpt-5 (encodes a carnitine palmitoyl transferase), and acs-2 (encodes a mitochondrial acyl-CoA synthetase) (Fig. 6C).
Remark  (Figure 6, S5) nhr-49 RNAi
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003639 nhr-49 K10C3.6 Caenorhabditis elegans

5 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:K10C3.6c K10C3.6c 1506   I: 9869718-9869787
CDS:K10C3.6b K10C3.6b 1431   I: 9871230-9871325
CDS:K10C3.6a K10C3.6a 1434   I: 9871230-9871325
CDS:K10C3.6d K10C3.6d 1461   I: 9869767-9869791
CDS:K10C3.6e K10C3.6e 1065   I: 9872822-9873046

0 Laboratories

3 Phenotype

Identifier Name Description
WBPhenotype:0000137 mRNA levels reduced Animals exhibit decreased levels of messenger RNA compared to control.
WBPhenotype:0001184 fat content increased Animals exhibit a greater amount of fat or lipids than observed in control animals.
WBPhenotype:0000319 large Animals have increased girth and increased length compared to control animals at the same developmental stage.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00044571

0 Strain