WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00111075 Phenotype Remark  Hypersensitivity to graphene oxide as assayed by lifespan reduction and increased ROS production compared to control animals. After graphene oxide addition, RNAi of mpk-1 resulted in the formation of more severe reduction in lifespan and the more significant induction of ROS production compared with wild-type nematodes. Authors later show that germline-specific RNAi knock-down of mpk-1using rrf-1(pk1417) did not significantly affect the susceptibility to graphene oxide (GO). These results imply that the neuronal MPK-1 may play a crucial role in regulating the response to GO exposure.
Remark  Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003401 mpk-1 F43C1.2 Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:F43C1.2a F43C1.2a 1131   III: 4217396-4217615
CDS:F43C1.2b F43C1.2b 1335   III: 4217396-4217615

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0001918 chemical hypersensitive Animals respond to a specific chemical at a lower concentration or a shorter exposure compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00051025

0 Strain