WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00114487 Phenotype Remark  RNAi of Alkbh1 (Y51H7C.5 (alkb-1)) triggers the mitochondrial unfolded protein response (UPRmt) in C. elegans, but not the unfolded protein response in the endoplasmic reticulum. RNAi of Alkbh1 (Y51H7C.5 (alkb-1)) leads to activation of the Phsp-6GFP reporter but not of the Phsp-4GFP reporter.
Remark  In SJ4100 the GFP sequence is under the control of the promoter of the mitochondrial chaperone hsp-6 is a UPRmt reporter strain. Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation (Y51H7C.5.1).
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00021783 alkb-1 Y51H7C.5 Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:Y51H7C.5 Y51H7C.5 1080   II: 1412528-1412657

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0001719 unfolded protein response variant Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria, compared to control. One such response is the increase in expression of chaperones.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00057256

1 Strain

WormBase ID
WBStrain00034068