WormMine: RNAi WBRNAi00108985

• WormBase ID: WBRNAi00108985
• Genotype: zcIs4 [Phsp-4::GFP]
• Phenotype Remark: RNAi resulted in reduced tunicamycin-induced expression of GFP from the hsp-4 promoter; "Interestingly, the observed strong impairment of the UPR-ER upon knockdown of pifk-1 (Table 1) was confirmed by qualitative analyses. The induction of hsp-4::gfp was reduced to 20% compared to control RNAi (Figure 9C). This is remarkable since at least to our knowledge PIFK-1 is the first protein which seems to be implied in signaling of UPRs in both organelles."
• Remark: (Table 1, Figure 9C) F35H12.4/pifk-1 RNAi

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00018076	pifk-1	F35H12.4	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:F35H12.4	F35H12.4	2001	X: 920307-920491

0 Laboratories

2 Phenotype

Identifier	Name	Description
WBPhenotype:0001278	transgene expression reduced	Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals.
WBPhenotype:0001719	unfolded protein response variant	Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria, compared to control. One such response is the increase in expression of chaperones.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00043917

0 Strain