WormMine: RNAi WBRNAi00110411

• WormBase ID: WBRNAi00110411
• Phenotype Remark: smn-1 RNAi increased tos-1 splice isoform 2, a product caused by both intron 1 retention and exon 3 skipping. Authors note "This result suggests that smn-1 is required for efficient splicing at the 3 prime splice sites of both introns 1 and 2 of tos-1". Authors later note that "smn-1 is required for efficient splicing at weak 3 prime splice sites", but not sites with a strong consensus.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00004887	smn-1	C41G7.1	Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:C41G7.1a	C41G7.1a	594	I: 9511283-9511497
CDS:C41G7.1b	C41G7.1b	624	I: 9511283-9511497

0 Laboratories

2 Phenotype

Identifier	Name	Description
WBPhenotype:0001834	mRNA splicing variant	Variations in the processes regulating the excision of intervening introns from the primary mRNA transcript, compared to control.
WBPhenotype:0001807	alternative splicing variant	Any variation in the process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition compared to control.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00046110

0 Strain