WormMine: RNAi WBRNAi00108447

• WormBase ID: WBRNAi00108447
• Phenotype Remark: RNAi of sek-1 protected worms against the lethal effects of rotenone. Rotenone causes mitochondrial stress as it interferes with the electron transport chain. When RNAi was preformed in a strain expressing the human LRRK2 gene (wlzIs2), animals were sensitized to the effects of rotenone (i.e. this RNAi abolishes LRRK2-mediated protection against mitochondrial stress).

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00004758	sek-1	R03G5.2	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:R03G5.2	R03G5.2	1011	X: 7816804-7816816

0 Laboratories

2 Phenotype

Identifier	Name	Description
WBPhenotype:0001282	mitochondrial metabolism variant	Variations in the chemical reactions and pathways of the mitochondria compared to control.
WBPhenotype:0001379	organism toxic chemical response variant	Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00035592

0 Strain