WormMine

WS294

Intermine data mining platform for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00107647 Phenotype Remark  "hmgs-1 RNAi induces strong and robust phenotypes including paralysis, reduced pharyngeal pumping, and sterility (Fig S3B and Movie S1). In agreement with previous reports on the involvement of hmgs-1 in the mevalonate pathway (26, 27), these hmgs-1 RNAi phenotypes were fully rescued by mevalonate supplementation, indicating that C. elegans HMGS-1 is functionally equivalent to its ortholog HMGCS1 (Fig S3B and Movie S2)."
Remark  (Fig S3B and Movie S1) hmgs-1 RNAi. Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00017769 hmgs-1 F25B4.6 Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:F25B4.6 F25B4.6 1389   V: 5682863-5683002

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0000644 paralyzed Animals do not move and are not responsive to external mechanical stimulation.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00045692

0 Strain