WormMine

WS294

Intermine data mining platform for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00064890 Genotype  unc-54::POLYQ(Q35)-YFP
Phenotype Remark  RNAi caused early onset of foci formation (polyglutamine-YFP aggregation) Remark  In strains expressing unc-54::POLYQ(Q35)-YFP, a diffuse YFP staining pattern is seen in all expressing cells from the moment they hatch through young adulthood. Onset of aggregation is invariable and occurs after the animals reach adulthood at the fifth day after hatching. L1 larva were feed RNAi bacteria in liquid culture and animals were assayed for fluorescent foci three days post-L1.
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003044 lir-1 F18A1.3 Caenorhabditis elegans

14 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:F18A1.3d F18A1.3d 903   II: 7672043-7672108
CDS:F18A1.3f F18A1.3f 711   II: 7681165-7681326
CDS:F18A1.3j F18A1.3j 714   II: 7681165-7681326
CDS:F18A1.3e F18A1.3e 750   II: 7681165-7681326
CDS:F18A1.3n F18A1.3n 456   II: 7681609-7681895
CDS:F18A1.3a F18A1.3a 891   II: 7672043-7672108
CDS:F18A1.3b F18A1.3b 930   II: 7672043-7672108
CDS:F18A1.3c F18A1.3c 756   II: 7672043-7672108
CDS:F18A1.3g F18A1.3g 426   II: 7681609-7681895
CDS:F18A1.3h F18A1.3h 465   II: 7681609-7681895
CDS:F18A1.3i F18A1.3i 894   II: 7672043-7672108
CDS:F18A1.3k F18A1.3k 429   II: 7681609-7681895
CDS:F18A1.3l F18A1.3l 921   II: 7672043-7672108
CDS:F18A1.3m F18A1.3m 741   II: 7681165-7681326

1 Laboratories

Primary Identifier
NL

2 Phenotype

Identifier Name Description
WBPhenotype:0000679 transgene subcellular localization variant Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals.
WBPhenotype:0001405 protein aggregation variant Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00006510

0 Strain