WormMine: RNAi WBRNAi00107995

• WormBase ID: WBRNAi00107995
• Genotype: hsp-60pr::gfp; clk-1(qm30)
• Phenotype Remark: "We next investigated ATFS-1-dependent hsp-60pr::gfp activation in strains harboring the well-characterized clk-1(qm30) or isp-1(qm150) mutations [26,27]... As both mutations affect respiration and display impaired development [22,23], we hypothesized that they would cause activation of the UPRmt. Indeed, hsp-60pr::gfp expression was consistently elevated in both strains consistent with the presence of mitochondrial stress. The isp-1(qm150) mutation caused considerably stronger hsp-60pr::gfp induction suggestive of a larger impact on mitochondrial function [29] (Figure 1B). Chaperone induction in both mutants required ATFS-1 as animals raised on atfs-1(RNAi) were unable to induce expression of hsp-60pr::gfp (data not shown)."
• Remark: (Data not shown) atfs-1 RNAi. Authors state RNAi clones obtained from the Ahringer and Vidal laboratories, Ahringer clone used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00013878	atfs-1	ZC376.7	Caenorhabditis elegans

4 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:ZC376.7b	ZC376.7b	1419	V: 14194483-14194578
CDS:ZC376.7c	ZC376.7c	1425	V: 14194483-14194578
CDS:ZC376.7d	ZC376.7d	846	V: 14196345-14196419
CDS:ZC376.7a	ZC376.7a	1467	V: 14194483-14194578

0 Laboratories

1 Phenotype

Identifier	Name	Description
WBPhenotype:0001278	transgene expression reduced	Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00041212

0 Strain