WormMine: Gene WBGene00220263

• WormBase Gene ID: WBGene00220263
• Gene Name: Bm2
• Sequence Name: Bm2
• Organism: Brugia malayi
• Automated Description: Predicted to enable cysteine-type deubiquitinase activity; manganese ion binding activity; and metalloaminopeptidase activity. Predicted to be involved in protein deubiquitination and proteolysis. Predicted to be located in cytoplasm. Is an ortholog of O. volvulus OVOC1937.
• Biotype: SO:0001217
• Genetic Position: :±

1 Organism

• Name: Brugia malayi
• Taxon Id: 6279

0 Synonyms

Genomics

10 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:Bm2f.1	Bm2f.1		[unknown]
Transcript:Bm2g.1	Bm2g.1		[unknown]
Transcript:Bm2c.1	Bm2c.1		[unknown]
Transcript:Bm2d.1	Bm2d.1		[unknown]
Transcript:Bm2e.1	Bm2e.1		[unknown]
Transcript:Bm2a.1	Bm2a.1		[unknown]
Transcript:Bm2b.1	Bm2b.1		[unknown]
Transcript:Bm2j.1	Bm2j.1		[unknown]
Transcript:Bm2h.1	Bm2h.1		[unknown]
Transcript:Bm2i.1	Bm2i.1		[unknown]

Other

10 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Bm2g	Bm2g		[unknown]
CDS:Bm2h	Bm2h		[unknown]
CDS:Bm2i	Bm2i		[unknown]
CDS:Bm2j	Bm2j		[unknown]
CDS:Bm2a	Bm2a		[unknown]
CDS:Bm2b	Bm2b		[unknown]
CDS:Bm2c	Bm2c		[unknown]
CDS:Bm2d	Bm2d		[unknown]
CDS:Bm2e	Bm2e		[unknown]
CDS:Bm2f	Bm2f		[unknown]

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

2 Data Sets

• WormBaseAcedbConverter
• GO Annotation data set

0 Downstream Intergenic Region

9 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_M120_vs_F120
	Transcripts that showed significantly lower expression in adult comparing to in microfilariae.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:Adult_vs_Micro_Downregulated
	Transcripts that showed significantly higher expression in L3 larva comparing to in adult.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:L3_vs_Adult_Upregulated
	Transcripts that showed significantly higher expression in L4 larva comparing to in adult.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:L4_vs_Adult_Upregulated
	Transcripts that showed significantly decreased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_F120_vs_F30
	Transcripts that showed significantly increased expression in male B. malayi 120 days after infecting gerbils, comparing to 42 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_M120_vs_M42
	Transcripts that showed significantly increased expression in male B. malayi 42 days after infecting gerbils, comparing to 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_M42_vs_M30
	Proteins that showed significantly increased expression in parasites exposed to 20-hydroxyecdysone.	An empirical filter of proteins with more than two peptides identified, a P value <0.05 and a greater than two-fold change of differential expression, was applied to the data. The Bonferroni correction was applied to correct the P value for the proteins analyzed.	WBPaper00049261:20-hydroxyecdysone_upregulated_protein
	Transcripts that showed significantly decreased expression after 48 hours of 300nM ivermectin exposure.	Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method).	WBPaper00049974:ivermectin_300nM_48h_downregulated

0 Expression Patterns

8 GO Annotation

0 Homologues

0 Locations

8 Ontology Annotations

0 Regulates Expr Cluster

0 Sequence

1 Sequence Ontology Term

• Name: gene

0 Strains

0 Upstream Intergenic Region