WormMine: Gene WBGene00000390

• WormBase Gene ID: WBGene00000390
• Gene Name: cdc-42
• Sequence Name: R07G3.1
• Brief Description: cdc-42 encodes a RHO GTPase; cdc-42 controls polarity of both individual cells and developing embryos by regulating the localization of PAR proteins; cdc-42 is also required for regulation of receptor-mediated endocytosis; CDC-42 is widely expressed and localizes to a number of different locations, including the cell cortex, centrosomes, recycling endosomes, and at the time of hypodermal cell fusion, to hypodermal cell boundaries.
• Organism: Caenorhabditis elegans
• Automated Description: Enables GTP binding activity and GTPase activity. Involved in several processes, including establishment of mitotic spindle orientation; positive regulation of nematode male tail tip morphogenesis; and regulation of cellular component organization. Located in centrosome; cytoplasm; and plasma membrane. Expressed in several structures, including AIY; P8.pa; hermaphrodite gonad; hypodermal cell; and nerve ring. Used to study cerebral cavernous malformation. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; bipolar disorder; fibrosarcoma; and rhinitis. Is an ortholog of human CDC42 (cell division cycle 42).
• Biotype: SO:0001217
• Genetic Position: II :0.5071±
• Length (nt): 1794

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Synonyms

• Value: WBGene00000390

Genomics

1 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:R07G3.1.1	R07G3.1.1	1346	II: 7616452-7618245

Other

1 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:R07G3.1	R07G3.1	576	II: 7616457-7616579

70 RNAi Result

• WBRNAi00107896
• WBRNAi00078512
• WBRNAi00078510
• WBRNAi00086069
• WBRNAi00091306
• WBRNAi00107681
• WBRNAi00062774
• WBRNAi00062775
• WBRNAi00101882
• WBRNAi00009047
• WBRNAi00051498
• WBRNAi00026057
• WBRNAi00061131
• WBRNAi00091303
• WBRNAi00034721
• WBRNAi00068319
• WBRNAi00068318
• WBRNAi00068321
• WBRNAi00068320
• WBRNAi00064511
• WBRNAi00064641
• WBRNAi00064702
• WBRNAi00064793
• WBRNAi00068831
• WBRNAi00068830
• WBRNAi00071920
• WBRNAi00071922
• WBRNAi00071924
• WBRNAi00065667
• WBRNAi00071854

36 Allele

• gk963801
• gk963053
• gk962682
• h12886
• gk475074
• gk675733
• gk328667
• gk902508
• gk635517
• gk839949
• gk920751
• gk641280
• gk315320
• gk570787
• WBVar00173506
• WBVar01308046
• yc100
• WBVar01626734
• WBVar00173507
• gk388
• ttTi26342
• ok825
• tm9607
• cp58
• WBVar01413631
• gk1768
• gk2326
• pk57
• gk147248
• gk147247

1 Chromosome

• WormBase ID: II
• Organism: Caenorhabditis elegans
• Length (nt): 15279421

1 Chromosome Location

• Feature . Primary Identifier: WBGene00000390
• Start: 7616452
• End: 7618245
• Strand: 1

4 Data Sets

• WormBaseAcedbConverter
• GO Annotation data set
• C. elegans genomic annotations (GFF3 Gene)
• Panther orthologue and paralogue predictions

0 Downstream Intergenic Region

107 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	oocyte proteins identified by two or more unique peptides during proteomics study.	In the pooled data set, 1453 C. elegans proteins were identified with a probability >= 0.9 according to ProteinProphet, of which 1165 proteins were identified by more than one unique peptide.	WBPaper00038289:oocyte_protein
	Transcripts expressed in neuronal cells, by analyzingfluorescence-activated cell sorted (FACS) neurons.	DESeq. False discovry rate (FDR) < 0.1.	WBPaper00048988:neuron_expressed
adult vs dauer larva	Transcripts that showed differential expression in adult vs dauer lava in N2 animals at 20C.	N.A.	WBPaper00050488:adult_vs_dauer_regulated_N2_20C
	mRNAs that showed decreased expression in 1 cell mebryo comparing to in oocyte, according to RNAseq analysis.	Gaussian error propagation. As cutoff for the up-regulated genes authors used log2 fold change > 1 and P < 0.05 and as cutoff for the down-regulated genes authors used log2 fold change < -1 and P < 0.05.	WBPaper00045420:fertilization_downregulated_transcript
	Genes that showed expression levels higher than the corresponding reference sample (embryonic 24hr reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:AVE-neuron_L1-larva_expressed
	Proteins interacting with NHR-49-GFP according to co-IP and LC-MS.	N.A.	WBPaper00064071:NHR-49_interacting
	Transcripts expressed in the epithelial tissues surrounding the pharynx that includes the arcade and intestinal valve (AIV) cells, according to PAT-Seq analysis using Pbath-15-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:arcade_intestinal-valve_expressed
	Transcripts expressed in body muscle, according to PAT-Seq analysis using Pmyo-3-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:body-muscle_expressed
	Transcripts expressed in GABAergic neuron, according to PAT-Seq analysis using Punc-47-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:GABAergic-neuron_expressed
	Transcripts expressed in hypodermis, according to PAT-Seq analysis using Pdpy-7-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:hypodermis_expressed
	Transcripts expressed in intestine, according to PAT-Seq analysis using Pges-1-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:intestine_expressed
	Transcripts expressed in NMDA neuron, according to PAT-Seq analysis using Pnmr-1-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:NMDA-neuron_expressed
	Transcripts expressed in pharynx, according to PAT-Seq analysis using Pmyo-2-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:pharynx_expressed
	Transcripts expressed in seam cells, according to PAT-Seq analysis using Pgrd-10-GFP-3XFLAG mRNA tagging.	Cufflinks FPKM value >=1.	WBPaper00050990:seam_expressed
	Transcripts that showed significantly altered expression after 24 hour exposure to stavudine (d4T) starting at L1 lava stage.	DESeq	WBPaper00053302:stavudine_24h_regulated
	Transcripts detected in body muscle nuclei according to a nuclear FACS-based strategy.	Cufflinks	WBPaper00065120:body-muscle-transcriptome
	Genes that showed expression levels higher than the corresponding reference sample (L2 all cell reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
	Genes that showed expression levels higher than the corresponding reference sample (L2 all cell reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:all-neurons_L2-larva_expressed
	Proteins that showed significantly decreased expression after 1-day-old wild type adults were exposed to cisplatin (300ug per mL) for 6 hours.	The differential expression analysis was performed in R. Differentially expressed proteins were identified by using a two-sided t-test on log-transformed data.	WBPaper00065373:Cisplatin_downregulated_WT
	Genes that showed expression levels higher than the corresponding reference sample (L3/L4 all cell reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
	Genes that showed expression levels higher than the corresponding reference sample (L2 all cell reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:excretory-cell_L2-larva_expressed
	Genes that showed expression levels higher than the corresponding reference sample (L2 all cell reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
	Genes that showed expression levels higher than the corresponding reference sample (L2 all cell reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
	Genes that showed expression levels higher than the corresponding reference sample (L3/L4 all cell reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:hypodermis_L3-L4-larva_expressed
	Genes that showed expression levels higher than the corresponding reference sample (L3/L4 all cell reference).	A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes.	WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
	Genes that were not enriched in either spermatogenic fem-3(q96gf) nor oogenic fog-2(q71) gonads, according to RNAseq analysis.	To identify differentially expressed transcripts, authors used R/Bioconductor package DESeq.	WBPaper00045521:Gender_Neutral
	Proteins identified in extracellular vesicle.	N.A.	WBPaper00062669:extracellular-vesicle_protein
Bacteria infection: Enterococcus faecalis OG1RF. Exposure for 16 hours.	Transcripts that showed significantly decreased expression in hpx-2(dg047) after animals were exposed to E. faecalis OG1RF for 16 hours comparing to exposure to E. Coli OP50.	Cuffcompare and Cuffdiff	WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
	Genes found to be regulated by low-copy overexpression of sir-2.1 with p < 0.014.	N.A.	WBPaper00026929:sir-2.1_overexpression_regulated
	Transcripts of coding genes that showed significantly increased expression in muscle.	DESeq2 (version 1.24.0). Transcripts with a false-discovery rate adjusted p-value less than 0.05 were considered significantly differentially expressed.	WBPaper00062325:muscle_enriched_coding-RNA

22 Expression Patterns

• Primary Identifier: Expr4280
• Subcellular Localization: Before and during the early stage of phase I, structured GFP-CDC-42 signals were not detected at the cell cortex. Small foci and short filaments of GFP-CDC-42 predominantly appeared at the anterior cortex during the late stages of phase I later than those of GFP-RHO-1.

• Primary Identifier: Expr4247
• Subcellular Localization: The constitutively active mutant, CDC-42 Q61L, becomes highly enriched on the anterior cortex in a pattern resembling that of the anterior PAR proteins (N = 35 from 8 lines). Early in the first cell cycle, before the maternal pronucleus migrates to the posterior, GFP::CDC-42 Q61L is enriched around the entire cortex. Then GFP begins to accumulate on the anterior cortex. After the first cell division, cortical CDC-42 Q61L is enriched around AB relative to P1, and by the four-cell stage, CDC-42 Q61L is present to a lower degree around P2.

• Primary Identifier: Expr4245
• Subcellular Localization: GFP::CDC-42 is present in the cytoplasm and is enriched in cortical patches around all cells during development (N = 12 from 10 lines). The cortical patches are especially evident on ruffled and invaginated cortex, and the GFP often appears slightly enriched in the perinuclear region, and on centrosomes.

• Primary Identifier: Expr4246
• Subcellular Localization: In four lines expressing GFP-tagged CDC-42 T17N, the distribution of the mutant protein is similar to that of unmodified CDC-42 (N = 19). See Expr4245

• Primary Identifier: Expr2009785
• Pattern: Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).

• Primary Identifier: Expr1030213
• Pattern: Tiling arrays expression graphs

• Primary Identifier: Expr14976
• Pattern: We found that Pcdc-42::GFP is broadly expressed in early embryogenesis. In larval and adult stages, the reporter is highly enriched in the nervous system, which is consistent with previous reports (Neukomm et al., 2014). cdc-42 is expressed in the AIY interneurons.

• Primary Identifier: Expr10054
• Subcellular Localization: GFP::CDC-42 was found mostly at the apical domain but was also visible at the lateral membrane and was absent from the basal membrane.

• Primary Identifier: Expr14317
• Pattern: A functional GFP::CDC-42 reporter was expressed in epidermal syncytia (hyp1-hyp11) as well as in lateral specialized epithelial seam cells.
• Subcellular Localization: GFP::CDC-42 accumulated in rounded, rod-like, or irregularly shaped structures throughout the cytosol that were enriched in the apical region of hyp7. GFP::CDC-42 was also observed in ring-shaped structures, suggesting that CDC-42 is associated with the membranes of vesicles. Furthermore, smaller CDC-42 puncta accumulated at the boundary between the main epidermal syncytium hyp7 and seam cells.

• Primary Identifier: Expr11675
• Subcellular Localization: In 2-cell to 32-cell embryos, CDC-42 mainly localized to cortexes at cell-cell contacts. At late stages of embryonic development, we also observed a widespread CDC-42 expression in neuronal tissues such as the nerve ring, supporting the involvement of CDC-42 in neuronal processes. During larval development and in adults, CDC-42 localized to cortexes in all cells, for example, in the vulva and in the tail. Previous work has shown that CED-1 and CED-6 in engulfing cells are selectively recruited to the plasma membrane surrounding apoptotic cells, generating a 'halo' pattern around the corpses. A similar accumulation of GFP::CDC-42 was observed around apoptotic cell corpses during all developmental stages. Importantly, CDC-42 was significantly enriched at membranes surrounding apoptotic cell corpses compared with cortical basal as well as background levels.

• Primary Identifier: Expr14266
• Pattern: CDC-42 expressed throughout the spermatheca at the apical and basal membranes.

• Primary Identifier: Expr12691
• Pattern: CDC-42 is expressed broadly in the developing uterine and vulval cells, including the AC.

• Primary Identifier: Expr12692
• Subcellular Localization: CDC-42 localizes to anchor cell invadopodia. CDC-42 is localized and activated in puncta at the invasive cell membrane.

• Primary Identifier: Expr2323
• Remark: No signal was detected using the antibody when it was blocked with its GST fusion protein.
• Pattern: Ubiquitously expressed throughout embryogenesis. However, at the stage when hypodermal cell fusion was occurring CDC42Ce was found to localize with CePAK at the cell boundaries.
• Subcellular Localization: cell boundaries

• Primary Identifier: Expr2028025
• Pattern: Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).

• Primary Identifier: Chronogram600
• Remark: Original chronogram file: chronogram.1629.xml
• Reporter Gene: [R07G3.1:gfp] transcriptional fusion.

• Primary Identifier: Expr11493
• Remark: Temporal description
• Pattern: A CDC-42::GFP fusion protein is diffusely distributed in the cytoplasm of the tail tip cells at the early L4 stage and then localizes to foci at the apical surfaces of the tail tip cells just before retraction begins at mid-L4. During retraction, CDC-42::GFP again becomes diffuse in the cytoplasm.
• Subcellular Localization: CDC-42::GFP is cytoplasmic prior to tail tip retraction, localizes to the membranes and discrete puncta during retraction (arrow), and becomes cytoplasmic again in late L4 and adults

• Primary Identifier: Expr1155177
• Pattern: Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015

• Primary Identifier: Expr13519
• Subcellular Localization: HA-CDC-42 was enriched at the plasma membrane, including adherens junctions, which we visualized by costaining for HMR-1.

• Primary Identifier: Expr3983
• Subcellular Localization: YFP-CDC-42 formed dynamic structures at the cortex that segregated to the anterior cortex during polarity establishment (n=8), recapitulating the behavior of anterior PAR proteins. Cortical YFP-CDC-42 disappeared around the time of pronuclear rotation.

• Primary Identifier: Expr14980
• Subcellular Localization: Both CDC-42 and PES-7 are enriched at presynaptic sites, colocalizing with the presynaptic marker GFP::RAB-3. In addition, when mCherry::PES-7 and GFP::CDC-42 are simultaneously expressed in AIY interneurons, they colocalize. These data indicate that both PES-7 and CDC-42 localize to presynaptic sites in the AIY interneurons, promoting synaptic assembly.

• Primary Identifier: Expr1016510
• Pattern: Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/levin2012

48 GO Annotation

17 Homologues

1 Locations

• Feature . Primary Identifier: WBGene00000390
• Start: 7616452
• End: 7618245
• Strand: 1

48 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

• Length: 1794

1 Sequence Ontology Term