WormMine: Gene WBGene00001913

• WormBase Gene ID: WBGene00001913
• Gene Name: his-39
• Sequence Name: F45F2.2
• Brief Description: his-39 encodes an H2B histone; by homology, HIS-39 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; loss of his-39 function via RNA-mediated interference (RNAi) does not result in any abnormalities; his-39 is a replication-dependent histone locus that resides in the HIS2 cluster on chromosome V.
• Organism: Caenorhabditis elegans
• Automated Description: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be part of nucleosome. Is an ortholog of human H2BK1 (H2B.K variant histone 1).
• Biotype: SO:0001217
• Genetic Position: V :1.44151 ±0.000477
• Length (nt): 204

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Synonyms

• Value: WBGene00001913

Genomics

1 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:F45F2.2.1	F45F2.2.1	204	V: 8536513-8536716

Other

1 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:F45F2.2	F45F2.2	204	V: 8536513-8536716

28 RNAi Result

• WBRNAi00095723
• WBRNAi00025513
• WBRNAi00026258
• WBRNAi00027343
• WBRNAi00064493
• WBRNAi00015036
• WBRNAi00090826
• WBRNAi00047423
• WBRNAi00068391
• WBRNAi00068392
• WBRNAi00068393
• WBRNAi00068394
• WBRNAi00068395
• WBRNAi00068620
• WBRNAi00068621
• WBRNAi00068622
• WBRNAi00068623
• WBRNAi00068624
• WBRNAi00068871
• WBRNAi00025511
• WBRNAi00111790
• WBRNAi00075452
• WBRNAi00096920
• WBRNAi00069020
• WBRNAi00103363
• WBRNAi00081664
• WBRNAi00110850
• WBRNAi00096980

6 Allele

• gk963301
• gk964351
• gk962860
• gk964052
• gk241591
• gk446461

1 Chromosome

• WormBase ID: V
• Organism: Caenorhabditis elegans
• Length (nt): 20924180

1 Chromosome Location

• Feature . Primary Identifier: WBGene00001913
• Start: 8536513
• End: 8536716
• Strand: 1

3 Data Sets

• WormBaseAcedbConverter
• GO Annotation data set
• C. elegans genomic annotations (GFF3 Gene)

1 Downstream Intergenic Region

• WormBase ID: intergenic_region_chrV_8536717..8537330
• Length (nt): 614
• Chromosome Location: V: 8536717-8537330
• Organism: Caenorhabditis elegans

38 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
adult vs dauer larva	Transcripts that showed differential expression in adult vs dauer lava in N2 animals at 20C.	N.A.	WBPaper00050488:adult_vs_dauer_regulated_N2_20C
	Transcripts that showed significantly higher expression in somatic gonad precursor cells (SGP) vs. head mesodermal cells (hmc).	DESeq2, fold change >= 2, FDR <= 0.01.	WBPaper00056826:SGP_biased
Heat shock: 35C for 1 hour.	Transcripts that showed significantly increased expression immediately after 1-day post L4 adult hermaphrodite N2 animals were exposed to 35C for 1 hour.	The DESeq2 (GalaxyVersion 2.11.40.6 + galaxy1) was used to determine differentiallyexpressed features from count tables of differential transcript abundances. log2FC > 1, FDR < 0.01.	WBPaper00065749:Heat-Shock_upregulated_N2
	Proteins interacting with NHR-49-GFP according to co-IP and LC-MS.	N.A.	WBPaper00064071:NHR-49_interacting
	Transcripts that showed significantly decreased expression in daf-16(mgDf50) comparing to in N2 at L1 larva stage.	DESeq v1.20.0 was used to analyze differential gene expression. Transcripts with adjusted p-value < 0.05 were considered differentialled expressed.	WBPaper00048971:daf-16(mgDf50)_downregulated_L1
Reduced humidity (98% relative humidity).	Genes that were down-regulated after one day exposure to reduced humidity (98% relative humidity) according to microarray analysis.	Multiple hypothesis testing with the Benjamini-Hochberg correction was applied on calculated p-values. A change in the expression level was considered to be significant if the adjusted p-value was less than 0.001.	WBPaper00044578:reduced-humidity_downregulated_microarray
	Proteins interacting with HA-PPM-1.D.	N.A.	WBPaper00062498:PPM-1.D_interacting
	Up-regulated genes (fold change > 1.5) in two CoQ-deficient clk-1 mutant strains (e2519, qm30) compared to wild types N2.	Fold-changes of intensities were calculated from the arithmetic mean of gene expression values between experimental and corresponding control group. Fold change >= 1.5 was used as cut-off.	WBPaper00045774:clk-1_upregulated
	Transcripts that showed significantly increased expression in animals lacking P granules by RNAi experiments targeting pgl-1, pgl-3, glh-1 and glh-4, and unc-119-GFP(+), comparing to in control animals, at 2-day post L4 adult hermaphrodite stage.	DESeq2, Benjamini-Hochberg multiple hypothesis corrected p-value < 0.05 and fold change > 2.	WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
	Transcripts that showed significantly increased expression in animals lacking P granules by RNAi experiments targeting pgl-1, pgl-3, glh-1 and glh-4, and unc-119-GFP(-), comparing to in control animals, at 2-day post L4 adult hermaphrodite stage.	DESeq2, Benjamini-Hochberg multiple hypothesis corrected p-value < 0.05 and fold change > 2.	WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
	Transcripts that showed significantly increased expression in pgl-1(ct131) animals (isolated from SS0002[pgl-1(ct131)him-3(e1147)], comparing to in control animals SS1174, at 1-day post L4 adult hermaphrodite stage.	DESeq2, Benjamini-Hochberg multiple hypothesis corrected p-value < 0.05 and fold change > 2.	WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
	Genes found to be regulated by low-copy overexpression of sir-2.1 with p < 0.014.	N.A.	WBPaper00026929:sir-2.1_overexpression_regulated
Heat shock: 34C 30min.	Transcripts that showed significantly increased expression in L2 larva stage C. elegans animals after incubated in a 34C water bath for 30min.	DESeq2 v 1.18.1, fold change > 2, FDR < 0.01.	WBPaper00058955:heatshock_upregulated_CE
	Transcripts that showed significantly increased expression in mdt-15(tm2182) comparing to in N2 at L4 larva stage.	p-value < 0.05, fold change > 2.	WBPaper00065288:mdt-15(tm2182)_upregulated
	Transcripts that showed differential expression in dauer mir-34(gk437) vs dauer mir-34(OverExpression) animals at 20C.	N.A.	WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
Bacteria infection: Xenorhabdus nematophila	Caenorhabditis elegans Genes with expression levels changed significantly after treatment of Xenorhabdus nematophila.	Differential expression were calculated by empirical eBayes method using eBayes function. P_value <= 0.01 and log2 fold change > 1 were used to call differentially expressed genes in all datasets.	WBPaper00041606:CE_X.nematophila_regulated
	Genes found to be regulated in daf-16(mgDf50) by resveratrol treatment with p < 0.01.	N.A.	WBPaper00026929:Resveratrol_regulated_daf-16
	Transcripts that showed differential expression in dauer N2 vs dauer mir-34(gk437) animals at 20C.	N.A.	WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
	Transcripts that showed significantly increased expression in animals lacking P granules by RNAi experiments targeting pgl-1, pgl-3, glh-1 and glh-4, and unc-119-GFP(-), comparing to in control animals, at 1-day post L4 adult hermaphrodite stage.	DESeq2, Benjamini-Hochberg multiple hypothesis corrected p-value < 0.05 and fold change > 2.	WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
	Transcripts that interact with 3xFLAG-DLC-1 as identified by immunoprecipitation followed by RNA sequencing.	DESeq2, fold change > 2,, p-value < 0.01	WBPaper00055334:DLC-1_interacting
Heat Shock: 35C 4 hours at L4 larva stage.	Transcripts that showed significantly increased expression after L4 larva N2 animals were heat stressed at 35C for 4 hours	DESeq2	WBPaper00057154:HeatShock_upregulated_mRNA
	mRNAs that showed significantly increased expression in monosomal fractions in N2 comparing to in daf-2(e1370), according to RNAseq study.	Differentially expressed genes were determined using cuffdiff across all pairs.	WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
	Transcripts that showed significantly increased expression in animals treated with 25ug per mL tunicamycin for 4 hours, comparing to control animals.	Fold-change > 1.5, ANOVA P values < 0.05.	WBPaper00055482:Tunicamycin_upregulated
	Transcripts that showed significantly decreased expression in swsn-2.2(RNAi) comparing to in control animals.	Cuffdiff was used to identify differentially expressed genes.	WBPaper00049018:swsn-2.2(RNAi)_downregulated
	Genes up or down regulated by 10e-09M of cholesterol . The normalized values used were G/R ratio > 2.6 for up-regulation and G/R ratio < 0.38 for down-regulation, which corresponds to 1.39 and -1.39 log(base2) G/R ratio, respectively.	The normalized values used were: G/R ratio > 2.6 for up-regulation and G/R ratio < 0.38 for down-regulation, which corresponds to 1.39 and -1.39 log(base2) G/R ratio, respectively.	WBPaper00005124:cholesterol_10-9M_regulated
	Genes that showed significantly changed expression during aging (ANOVA, p < 0.0001)	ANOVA, p < 0.0001.	WBPaper00032062:age_regulated_genes
	Genes with at least 2-fold greater expression in par-1 emrbyos (with excess pharyngeal cells) comparing to skn-1 embryos (with no pharynx) during microarray analysis.	Genes with at least 2 fold change in expression are considered differentially expressed.	WBPaper00024505:pharyngeal_enriched
Temperature shift: 15C vs 20 C.	Proteins that showed significantly decreased expression in CF512 (fer-15(b26)II;fem-1(hc17)IV) treated with empty RNAi vector at 15C comparing to at 20C.	Two-tailed Student's t-test (n=3, P-value <0.05 was considered significant).	WBPaper00057288:Cold_downregulated_protein
	Transcripts that showed significantly increased expression in ins-11(tm1053) young adult animals comparing to in N2.	For log2 fold changes > 0.00001 the values > 81.25th percentile were defined as up-regulated and for log2 fold changes < -0.00001 the values < 18. 75th percentile were defined as down-regulated.	WBPaper00053664:ins-11(tm1053)_upregulated
spaceflight-induced microgravity on the ISS (International Space Station).	Transcripts that showed significantly increased expression in animals grew under spaceflight-induced microgravity on the ISS (International Space Station).	N.A.	WBPaper00061274:microgravity_upregulated

6 Expression Patterns

• Primary Identifier: Expr1031119
• Pattern: Tiling arrays expression graphs

• Primary Identifier: Expr1151267
• Pattern: Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015

• Primary Identifier: Expr2030691
• Pattern: Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).

• Primary Identifier: Expr1200219
• Pattern: Data from the TransgeneOme project

• Primary Identifier: Expr2012455
• Pattern: Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).

• Primary Identifier: Expr1017581
• Pattern: Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/levin2012

4 GO Annotation

0 Homologues

1 Locations

• Feature . Primary Identifier: WBGene00001913
• Start: 8536513
• End: 8536716
• Strand: 1

4 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

• Length: 204

1 Sequence Ontology Term