WormMine: Gene WBGene00206390

• WormBase Gene ID: WBGene00206390
• Gene Name: F14F7.7
• Sequence Name: F14F7.7
• Organism: Caenorhabditis elegans
• Automated Description: Enriched in ABplppppap; ABprppppap; egg-laying apparatus; rectal epithelial cell; and spermathecal-uterine junction based on single-cell RNA-seq studies. Is affected by several genes including mut-16; atfs-1; and ash-2 based on microarray and RNA-seq studies. Is affected by rifampin; allantoin; and silicon dioxide nanoparticle based on RNA-seq studies.
• Biotype: SO:0001217
• Genetic Position: :±
• Length (nt): 962

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Synonyms

• Value: WBGene00206390

Genomics

2 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:F14F7.7.1	F14F7.7.1	517	III: 13030904-13031858
Transcript:F14F7.7.2	F14F7.7.2	390	III: 13031084-13031865

Other

1 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:F14F7.7	F14F7.7	192	III: 13031271-13031292

2 RNAi Result

• WBRNAi00001138
• WBRNAi00030956

24 Allele

• gk963887
• gk963904
• gk963552
• gk189673
• gk963763
• gk963762
• WBVar00244229
• WBVar00244228
• WBVar00244227
• WBVar00244230
• WBVar00103399
• WBVar01449709
• WBVar01449708
• ttTi39466
• gk868931
• gk327540
• gk580672
• gk828492
• gk669177
• gk494653
• gk427276
• WBVar01913377
• WBVar01964082
• WBVar01964083

1 Chromosome

• WormBase ID: III
• Organism: Caenorhabditis elegans
• Length (nt): 13783801

1 Chromosome Location

• Feature . Primary Identifier: WBGene00206390
• Start: 13030904
• End: 13031865
• Strand: 1

2 Data Sets

• WormBaseAcedbConverter
• C. elegans genomic annotations (GFF3 Gene)

1 Downstream Intergenic Region

• WormBase ID: intergenic_region_chrIII_13031866..13032000
• Length (nt): 135
• Chromosome Location: III: 13031866-13032000
• Organism: Caenorhabditis elegans

22 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly decreased expression in AGP22 [nhr-49(nr2041)I;glp-1(e2141)III] comparing to in CF1903 [glp-1(e2144)III] at Day 2 adults.	Fold change > 2, p Value of < 0.05 and a false discovery rate (FDR) of < 0.05.	WBPaper00061530:nhr-49(e2144)_downregulated
	Transcripts that showed significantly increased expression in ilc-17.1(syb5296) comparing to in N2 animals at L4 larva stage.	DESeq2, fold change > 2, FDR < 0.05.	WBPaper00066594:ilc-17.1(syb5296)_upregulated
	Transcripts that showed significantly increased expression in mut-16(pk710), comparing to in N2 animals.	DESeq2 v. 1.22.2, adjusted p-value <= 0.05.	WBPaper00059605:mut-16(pk710)_upregulated
	Transcripts that showed significantly decreased expression after animals were treated with 50uM Rifampicin and 250uM Allantoin from day 1 to day 3 adult hermaphradite.	DESeq2(v1.14.1), fold change > 2, p-value < 0.05	WBPaper00055354:Rifampicin-Allantoin_downregulated
	Transcripts that showed significantly decreased expression in ash-2(RNAi) comparing to in wild type animals injected with vector.	Differential mRNA expression using DESeq2. mRNAs with a FDR < 0.05 and fold change > 2 considered differentially expressed.	WBPaper00066232:ash-2(RNAi)_downregulated_WT
	siRNAs that showed significantly lower expression (log2fold > 2, padj < 0.01) in hermaphrodite gonad (somatic gonad plus germine) than in male gonad (somatic gonad plus germine).	DESeq2 v1.13.8, fold change > 2, FDR < 0.01.	WBPaper00056161:male_enriched_siRNA
Bacteria: B.subtilis	Transcripts that showed significantly increased expression when animals were fed by probiotic bacteria strain B.subtilis PXN21 comparing to animals fed with OP50 from L1 till day 1 adult.	edgeR 3.16.5, FDR < 0.05, fold change > 2.	WBPaper00059117:B.subtilis_upregulated
	Transcripts that showed significantly decreased expression in BAT525 [hmg-3 (tm2539) / dpy-5(e61) unc-13(e1091) I.] comparing to in N2 at 1-day post L4 adult hermaphrodite stage	DESeq 2, fold change > 4, adjusted p-value < 0.05.	WBPaper00055013:hmg-3(bar24)_downregulated
moderate static magnetic field	Transcripts that showed significantly increased expression after exposure to moderate static magnetic field.	N.A.	WBPaper00064509:static-magnetic-field_upregulated
	Transcripts that showed significantly decreased expression in atfs-1(et18) comparing to in N2 animals at L4 larva stage.	edgeR, fold change > 2, FDR < 0.05	WBPaper00060909:atfs-1(et18)_downregulated
	Top 300 transcripts enriched in B cell according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:B
	Top 300 transcripts enriched in ABprppppap, ABplppppap according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:Parents_of_U_F_B_DVA
	Genes down regulated in nhr-114(RNAi) comparing to glp-1(q224ts).	Differentially expressed genes had a fold change cutoff of 2.0 and an unpaired t test p value cutoff of 0.05 for WT+Trp versus WT and 0.01 for nhr-114 versus glp-1.	WBPaper00042194:nhr-114(RNAi)_downregulated
	Top 300 transcripts enriched in Y cell according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:Y
	Transcripts that showed significantly increased expression in spt-16(RNAi) comparing to in vector control worm at L4 larva stage.	DESeq 2, fold change > 4, adjusted p-value < 0.05.	WBPaper00055013:spt-16(RNAi)_downregulated
	Single-cell RNA-Seq cell group 11_3 expressed in seam.	scVI 0.6.0	WBPaper00065841:11_3
	Single-cell RNA-Seq cell group 146_0 expressed in epithelium.	scVI 0.6.0	WBPaper00065841:146_0
	Single-cell RNA-Seq cell group 11_0 expressed in vulva.	scVI 0.6.0	WBPaper00065841:11_0
	Single-cell RNA-Seq cell group 11_1 expressed in epithelium.	scVI 0.6.0	WBPaper00065841:11_1
	Transcripts that showed significantly decreased expression in hmg-4(RNAi) comparing to in vector control worm at L4 larva stage.	DESeq 2, fold change > 4, adjusted p-value < 0.05.	WBPaper00055013:hmg-4(RNAi)_downregulated
Fungi: Myzocytiopsis humicola extract	Transcripts that showed significantly increased expression in N2 L4 larva animals after 4 hours of exposure to oomycete Myzocytiopsis humicola extract.	Differentially expressed genes as determined by Kallisto and Sleuth (pval < 0.01, qval < 0.1, fold change > 2).	WBPaper00065995:M.humicola-extract_upregulated_N2
	Transcripts that showed significantly decreased expression after exposed to 10ug per ml SiO2 nanoparticles from L1 larva to 1-day post L4 adult hermaphrodite stage.	edgeR, fold change > 2 (set by curator), FDR < 0.05.	WBPaper00059426:SiO2-nanoparticles_downregulated

3 Expression Patterns

• Primary Identifier: Expr2020799
• Pattern: Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).

• Primary Identifier: Expr2002582
• Pattern: Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).

• Primary Identifier: Expr1148593
• Pattern: Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015

0 GO Annotation

0 Homologues

1 Locations

• Feature . Primary Identifier: WBGene00206390
• Start: 13030904
• End: 13031865
• Strand: 1

0 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

• Length: 962

1 Sequence Ontology Term