WormMine: Gene WBGene00003351

• WormBase Gene ID: WBGene00003351
• Gene Name: mir-257
• Sequence Name: Y102A5D.4
• Brief Description: mir-257 encodes a microRNA, a small non-protein coding RNA; mir-257 is uniformly expressed from the embryonic stage to the adult stage; many of the known microRNAs are involved in post-transcriptional regulation of genes; the precise function of miR-257 is unknown.
• Organism: Caenorhabditis elegans
• Automated Description: Is affected by several genes including alg-1; alg-2; and alg-5 based on RNA-seq studies. Is affected by nicotine based on RNA-seq studies.
• Biotype: SO:0001265
• Genetic Position: V :12.8033 ±0.001776
• Length (nt): 102

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Synonyms

• Value: WBGene00003351

Genomics

1 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:Y102A5D.4a	Y102A5D.4a	22	V: 17140683-17140704

Other

0 CDSs

0 RNAi Result

31 Allele

• gk963271
• gk963489
• gk963304
• WBVar02123303
• gk964050
• gk963587
• gk963588
• WBVar02124497
• WBVar02124059
• WBVar02124270
• WBVar02122864
• gk964305
• WBVar02121796
• WBVar02123142
• WBVar02124430
• WBVar02122255
• gk962630
• gk963919
• WBVar01844014
• WBVar00091133
• WBVar01844013
• WBVar01844012
• WBVar01844017
• WBVar01844016
• WBVar01844015
• WBVar02076183
• gk868232
• n4548
• WBVar01780785
• WBVar01780786

1 Chromosome

• WormBase ID: V
• Organism: Caenorhabditis elegans
• Length (nt): 20924180

1 Chromosome Location

• Feature . Primary Identifier: WBGene00003351
• Start: 17140668
• End: 17140769
• Strand: 1

2 Data Sets

• WormBaseAcedbConverter
• C. elegans genomic annotations (GFF3 Gene)

1 Downstream Intergenic Region

• WormBase ID: intergenic_region_chrV_17140770..17142204
• Length (nt): 1435
• Chromosome Location: V: 17140770-17142204
• Organism: Caenorhabditis elegans

7 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Genes with small RNAs downregulated in all four meg-3(ax3055) meg-4(ax3052) strains comparing to N2	DESeq2	WBPaper00057162:meg-3_meg-4_downregulated_sRNA
	MicroRNAs that showed significantly decreased expression in alg-5(ram2), comparing to in N2.	DESeq2, Fold change > 1.5.	WBPaper00051404:alg-5(ram2)_downregulated_miRNA
	MicroRNAs that showed significantly decreased expression in alg-2(ok304), comparing to in N2.	DESeq2, Fold change > 1.5.	WBPaper00051404:alg-2(ok304)_downregulated_miRNA
	MicroRNAs that showed significantly decreased expression in alg-5(tm1163), comparing to in N2.	DESeq2, Fold change > 1.5.	WBPaper00051404:alg-5(tm1163)_downregulated_miRNA
	miRNAs in F1 generation up regulated by exposure to 20uM and 20mM nicotine during F0 generation.	Statistical analysis was based on t-test for independent samples via SPSS to compare each of the nicotine treatments with control (i.e. low vs. control and high vs. control). Welch test correction was performed to account for unequal variance in each of the compared groups (control and treatment). In addition, to increase the statistical stringency, miRNAs differential expression was deemed significant only if it fulfilled two criteria: p value , 0.05 and expression changed by at least 50% relative to control.	WBPaper00049006:nicotine_upregulated_F1
	MicroRNAs that showed significantly increased expression in alg-1(gk214), comparing to in N2.	DESeq2, Fold change > 1.5.	WBPaper00051404:alg-1(gk214)_upregulated_miRNA
space radition and microgravity	Micro RNAs that showed increased expression in space flight N2 samples comparing to in ground control, affected by space radition and microgravity.	Differentially expressed miRNAs (>1.5-fold change and <0.67) and mRNAs (>2-fold change and <0.5) were identified through fold-change filtering.	WBPaper00048474:SpaceRadiation-Microgravity_upregulated_N2

2 Expression Patterns

• Primary Identifier: Expr8434
• Remark: Picture: N.A.
• Pattern: No expression detected.

• Primary Identifier: Expr10965

0 GO Annotation

0 Homologues

1 Locations

• Feature . Primary Identifier: WBGene00003351
• Start: 17140668
• End: 17140769
• Strand: 1

0 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

• Length: 102

1 Sequence Ontology Term