WormMine: Gene WBGene00003352

• WormBase Gene ID: WBGene00003352
• Gene Name: mir-258.1
• Sequence Name: AC8.8
• Brief Description: mir-258.1 encodes a microRNA, a small non-protein coding RNA; there are two copies of mir-258 in the genome: mir-258.1 and mir-258.2; mir-258.1 is uniformly expressed from the embryonic stage to the adult stage; many of the known microRNAs are involved in post-transcriptional regulation of genes; the precise function of miR-258.1 is unknown.
• Organism: Caenorhabditis elegans
• Automated Description: Is affected by alg-1; alg-2; and alg-5 based on RNA-seq studies. Is affected by nicotine based on quantitative PCR studies.
• Biotype: SO:0001265
• Genetic Position: X :-20.2369 ±0.035776
• Length (nt): 96

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Synonyms

• Value: WBGene00003352

Genomics

1 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:AC8.8a	AC8.8a	21	X: 237374-237394

Other

0 CDSs

0 RNAi Result

14 Allele

• gk963652
• gk962800
• gk964065
• gk964321
• WBVar02123605
• WBVar02121671
• WBVar02124071
• WBVar02123945
• WBVar02123727
• WBVar02123606
• WBVar02123607
• WBVar02121495
• WBVar02121496
• WBVar02122172

1 Chromosome

• WormBase ID: X
• Organism: Caenorhabditis elegans
• Length (nt): 17718942

1 Chromosome Location

• Feature . Primary Identifier: WBGene00003352
• Start: 237369
• End: 237464
• Strand: 1

2 Data Sets

• WormBaseAcedbConverter
• C. elegans genomic annotations (GFF3 Gene)

1 Downstream Intergenic Region

• WormBase ID: intergenic_region_chrX_237465..237495
• Length (nt): 31
• Chromosome Location: X: 237465-237495
• Organism: Caenorhabditis elegans

7 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly increased expression in animals with pan-neuronal expression of human amyloid beta (snb-1p-Amyloid-beta(1-42) + mtl-2p-GFP), comparing to in N2 animals.	edgeR p-value < 0.01 and fold change > 4.	WBPaper00061613:human-amyloid-beta_upregulated
	MicroRNAs that showed significantly decreased expression in alg-5(ram2), comparing to in N2.	DESeq2, Fold change > 1.5.	WBPaper00051404:alg-5(ram2)_downregulated_miRNA
	miRNA that showed increased expression after 20mM nicotine treatment	Statistical analysis was based on t-test for independent samples via SPSS. The results were further narrowed based on two criteria. Only the genes whose expression changed with a P < 0.05 and a fold change > 0.5, when compared to control, were considered as differentially expressed. Fold change was calculated as 2**(DeltaCt(treatment)-DeltaCt(control))-1. DeltaCt = Ct(miRNA)-Ct(aveMRNA).	WBPaper00042480:20mM_nicotine_upregulated
	MicroRNAs that showed significantly decreased expression in alg-1(gk214), comparing to in N2.	DESeq2, Fold change > 1.5.	WBPaper00051404:alg-1(gk214)_downregulated_miRNA
	MicroRNAs that showed significantly increased expression in alg-2(ok304), comparing to in N2.	DESeq2, Fold change > 1.5.	WBPaper00051404:alg-2(ok304)_upregulated_miRNA
	MicroRNAs that showed significantly increased expression in alg-5(tm1163), comparing to in N2.	DESeq2, Fold change > 1.5.	WBPaper00051404:alg-5(tm1163)_upregulated_miRNA
space radition	Micro RNAs that showed decreased expression in space flight N2 samples (animals were put in a centrifugal device in space) comparing to in ground control, affected by space radition but not microgravity.	Differentially expressed miRNAs (>1.5-fold change and <0.67) and mRNAs (>2-fold change and <0.5) were identified through fold-change filtering.	WBPaper00048474:SpaceRadiation_downregulated_N2

1 Expression Patterns

• Primary Identifier: Expr8435
• Remark: Picture: N.A.
• Pattern: No expression detected.

0 GO Annotation

0 Homologues

1 Locations

• Feature . Primary Identifier: WBGene00003352
• Start: 237369
• End: 237464
• Strand: 1

0 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

• Length: 96

1 Sequence Ontology Term