WormMine: GOTerm GO:0004843 cysteine-type deubiquitinase activity GO

• Namespace: molecular_function
• Obsolete: false
• Description: An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.

0 Cross References

1 Data Sets

• GO Annotation data set

1 Ontology

• Name: GO

353 Ontology Annotations

9 Parents

Identifier	Name	Description
GO:0003674	molecular_function	A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824	catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787	hydrolase activity	Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
GO:0140096	catalytic activity, acting on a protein	Catalytic activity that acts to modify a protein.
GO:0008233	peptidase activity	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
GO:0008234	cysteine-type peptidase activity	Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
GO:0101005	deubiquitinase activity	An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
GO:0004843	cysteine-type deubiquitinase activity	An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
GO:0019783	ubiquitin-like protein peptidase activity	An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins.

28 Relations

Relationship	Parent Term . Identifier	Child Term . Identifier
is_a	GO:0101005	GO:0004843
is_a	GO:0008234	GO:0004843
is_a	GO:0019783	GO:0004843
is_a	GO:0008233	GO:0004843
is_a	GO:0003674	GO:0004843
is_a	GO:0140096	GO:0004843
is_a	GO:0016787	GO:0004843
is_a	GO:0003824	GO:0004843
has part	GO:0004843	GO:0016579
has part	GO:0004843	GO:0035520
has part	GO:0004843	GO:0035523
has part	GO:0004843	GO:0035871
has part	GO:0004843	GO:0044313
is_a	GO:0004843	GO:0061815
has part	GO:0004843	GO:0070536
has part	GO:0004843	GO:0071108
has part	GO:0004843	GO:0071947
has part	GO:0004843	GO:1990108
has part	GO:0004843	GO:1990167
has part	GO:0004843	GO:1990168
regulates	GO:0004843	GO:2000152
regulates	GO:0004843	GO:2000152
negatively regulates	GO:0004843	GO:2000157
negatively regulates	GO:0004843	GO:2000157
regulates	GO:0004843	GO:2000157
positively regulates	GO:0004843	GO:2000158
positively regulates	GO:0004843	GO:2000158
regulates	GO:0004843	GO:2000158

15 Synonyms

• Name: ubiquitinyl hydrolase activity
• Type: synonym

• Name: ubiquitin C-terminal hydrolase
• Type: synonym

• Name: thiol-dependent ubiquitinyl hydrolase activity
• Type: synonym

• Name: ubiquitin-specific protease activity
• Type: synonym

• Name: ubiquitin hydrolase activity
• Type: synonym

• Name: UBP
• Type: synonym

• Name: ubiquitinyl hydrolase 1 activity
• Type: synonym

• Name: GO:0036459
• Type: alt_id

• Name: UCH2
• Type: synonym

• Name: deubiquitinase activity
• Type: synonym

• Name: deubiquitinase
• Type: synonym

• Name: deubiquitylase
• Type: synonym

• Name: deubiquitinating enzyme
• Type: synonym

• Name: thiol-dependent ubiquitin-specific protease activity
• Type: synonym

• Name: thiol-dependent deubiquitinase
• Type: synonym