WormMine: ExpressionPattern Expr3920

• Pattern: The ALP-1BCD/Enigma proteins are first detected during embryogenesis at the comma-stage in the cell-cell junctions of the embryonic hypodermis and in the hypodermal cell nuclei. At this stage, proteins begin to localize to circumferential fibers, similar to ALP-1A. At a later stage (fourfold), these circumferential bundles are more apparent, as is the late appearance of the ALP-1BCD/Enigma::GFPs in the developing body wall muscle. In a deeper optical section of the same embryo, it is evident that the ALP-1BCD/Enigma::GFP fusion proteins localize to cell-cell junctions in the developing pharynx. At this stage, the pharynx is still developing, and the arcade cells that are required to attach the anterior part of the pharynx to the mouth have not yet become epithelialized. Once the pharynx begins to differentiate, an enrichment of the ALP-1BCD/Enigma::GFPs was seen in the pharyngeal muscles and in specialized pharyngeal epithelial cells called marginal cells. This pharyngeal expression persists throughout development and is most prevalent in adults.
• Primary Identifier: Expr3920
• Subcellular Localization: Expressed in the cell-cell junctions of the embryonic hypodermis and in the hypodermal cell nuclei.

4 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
type of cells that make up muscle layers in the pharynx.	pharyngeal muscle cell		WBbt:0005451
Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion.	body wall musculature	body muscle	WBbt:0005813
Epidermal layer.	hypodermis	epidermis	WBbt:0005733
a type of pharyngeal cell that connects basement membrane to the apices of triangle-shaped pharyngeal lumen.	marginal cell		WBbt:0003673

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00001132	alp-1	T11B7.4	Caenorhabditis elegans

7 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The stage that begins when a C.elegans individual is fully-developed and has reached maturity.		adult Ce	WBls:0000041
	The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch.		L3 larva Ce	WBls:0000035
	The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch.		L2 larva Ce	WBls:0000027
	The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch.		L4 larva Ce	WBls:0000038
	The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch.		L1 larva Ce	WBls:0000024
	The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo.		fully-elongated embryo Ce	WBls:0000021
	The C. elegans life stage spanning 350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation until elongation is over.		elongating embryo Ce	WBls:0000015