WormMine: ExpressionPattern Expr58

• Pattern: Antibody staining: No worm Ab available. Two D.m. Ab fail to stain anything in the worm that looks real. lacZ reporter gene expression: Multiple constructs with multiple lines. Expression begins late in embryogenesis at about 11/2 fold stage in a few cells in the head (neuronal precursors?). Then strong expression by 3-fold stage in most tissue including neurons, all muscle, hypodermis. Not in gut. Expression continues in all tissues (except gut) into adulthood.
• Primary Identifier: Expr58
• Remark: MADS box transcription factor related to SRF factors. In vertebrates, MEF2 is involved in the activation of muscle specific genes. It is also expressed in neuronal tissue but its role there is unstudied. Vertebrate Homologs: Human and mouse protein(s) MEF2a, MEF2b, MEF2c, MEF2d. Invertebrate Homologs: Drosophila protein D-MEF2 MEF2-gene deleted by mnDf111 on I. late embryo(author) = fully-elongated embryo(curator). no expression in gut

3 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Epidermal layer.	hypodermis	epidermis	WBbt:0005733
Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses.	neuron	neurone	WBbt:0003679
Contractile cell that makes up muscle tissue.	muscle cell		WBbt:0003675

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00003182	mef-2	W10D5.1	Caenorhabditis elegans

9 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The stage that begins when a C.elegans individual is fully-developed and has reached maturity.		adult Ce	WBls:0000041
	The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch.		L3 larva Ce	WBls:0000035
	The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch.		L2 larva Ce	WBls:0000027
	The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch.		L4 larva Ce	WBls:0000038
	The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch.		L1 larva Ce	WBls:0000024
	The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo.		fully-elongated embryo Ce	WBls:0000021
	The C. elegans life stage spanning 460-520min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and double fold. A stage between 1.5-fold embryo and 3-fold embryo.		2-fold embryo Ce	WBls:0000019
	The C. elegans life stage spanning 520-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and tripple fold. A stage between 2-fold embryo and fully-elongated embryo. Also called pretzel embryo or pretzel stage.		3-fold embryo Ce	WBls:0000020
	The C. elegans life stage spanning 420-460min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and fold back 50%. A stage between comma embryo and 2-fold embryo.		1.5-fold embryo Ce	WBls:0000018