WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

Expression Pattern :

Pattern  Expression of lin-11::GFP is first observed after the time when most postmitotic neurons are born (at approx. 300 minutes postfertilization). In larvae, the LIN-11::GFP fusion protein is localized to the nuclei of multiple neurons in the head and lumbar ganglia. In addition, lin-11 expression is observed in uterine and vulval cells, as well as in the VC motor neurons. In the lumbar ganglia, lin-11 expression is observed in the PVPL/R and PVQ neurons, and in an additional unpaired neuron identified as DVC or DVA. In contrast to shorter lin-11::GFP fusion genes, the rescuing lin-11::GFP fusion gene is not expressed in the PHA sensory neurons. In the head, lin-11 expression was observed in the sensory neurons ADF and ADL, in the interneurons AIZ, RIC and AVG, and in another neuron type tentatively identified as either AVH or AVJ. However, expression in a number of additional neurons was also observed using the full-length lin-11::GFP fusion gene. lin-11 expression was observed in the AVA and AVE interneurons. Faint and occasional expression was also detected in the ASH polymodal sensory neurons. lin-11 expression was observed in the AWA neurons in embryos and young larvae, but not in later stages. Expression of lin-11 in the AWA neurons is observed consistently in three-fold embryos, where expression of lin-11 overlaps with that of ODR-7 (32/32 AWA neurons examined). Expression decreases by hatching such that in L1 larvae, expression in the AWA neurons is fainter and observed only occasionally, and is absent in later larvae and adults. lin-11 expression was also observed strongly and consistently in the ASG chemosensory neurons. Expression in the ASG neurons is observed throughout postembryonic development. lin-11 expression was also detected in a few other non-sensory neurons in the head and tail that were not identified definitively. Primary Identifier  Expr2830
Subcellular Localization  Expressed in nuclei of multiple neurons in the head and lumbar ganglia.
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38 Anatomy Terms

Definition Name Synonym Primary Identifier
Neuron class of six motoneurons in the ventral cord, which innervate ventral body muscles and the vm2 muscles of the vulva. VC neuron   WBbt:0005304
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASGL lineage name: ABplaapapap WBbt:0003892
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASGR lineage name: ABpraapapap WBbt:0003891
Amphid neuron, prob. chemosensory ADFL lineage name: ABalpppppaa WBbt:0004003
Amphid neuron, prob. chemosensory ADFR lineage name: ABpraaappaa WBbt:0003999
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASHL lineage name: ABplpaappaa WBbt:0003890
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASHR lineage name: ABprpaappaa WBbt:0003889
Interneuron, projects along ventral cord to ring PVQL lineage name: ABplapppaaa WBbt:0004076
Interneuron, projects along ventral cord to ring PVQR lineage name: ABprapppaaa WBbt:0004074
Amphid neuron, prob. chemosensory ADLL lineage name: ABalppppaad WBbt:0003997
Amphid neuron, prob. chemosensory ADLR lineage name: ABpraaapaad WBbt:0003995
Amphid interneuron AIZR lineage name: ABprapaaapav WBbt:0003957
Ring interneuron RICL lineage name: ABplppaaaapp WBbt:0003941
Ring interneuron RICR lineage name: ABprppaaaapp WBbt:0003940
Amphid interneuron AIZL lineage name: ABplapaaapav WBbt:0003959
adult vulval toroid cell, F, formed by fusion of precursors of lineage names P6.papl, P6.papr, P6.ppal and P6.ppar. vulF   WBbt:0006768
adult vulval toroid cell, E, formed by fusion of precursors of lineage names P6.paal, P6.paar, P6.pppl and P6.pppr. vulE   WBbt:0006767
Ventral cord interneuron, synapses onto VA, DA, and AS motor neurons; formerly called alpha AVAL lineage name: ABalppaaapa WBbt:0003870
Ventral cord interneuron, synapses onto VA, DA, and AS motor neurons; formerly called alpha AVAR lineage name: ABalaappapa WBbt:0003869
Neuron class of one ring interneuron, cell body in dorsorectal ganglion, has a large vesicle-filled process in ring. DVA lineage name: ABprppppapp WBbt:0004823
adult vulval toroid cell, C, formed by fusion of precursors of lineage names P5.ppal, P5.ppar, P7.papl and P7.papr. vulC   WBbt:0006765
adult vulval toroid cell, D, formed by fusion of precursors of lineage names P5.ppp and P7.paa. vulD   WBbt:0006766
adult vulval toroid cell, B2. vulB2   WBbt:0006764
adult vulval toroid cell, B1, formed by fusion of precursors of lineage names P5.papa and P7.ppap. vulB1   WBbt:0006763
adult vulval toroid cell, A, formed by fusion of precursors of lineage names P5.paaa, P5.paap, P7.pppa and P7.pppp vulA   WBbt:0006762
toroidal epithelial cell that make up the bulk of the uterus, four cells anterior and four cells posterior to the vulva. uterine toroidal epithelial cell ut cell WBbt:0006784
Interneuron, cell body in lumbar ganglion, projects along ventral cord to nerve ring PVPR lineage name: ABprppppaaa WBbt:0004078
Interneuron, cell body in lumbar ganglion, projects along ventral cord to nerve ring PVPL lineage name: ABplppppaaa WBbt:0004082
Amphid wing cells, neurons having ciliated sheet-like sensory endings closely associated with amphid sheath AWAR lineage name: ABpraapapaa WBbt:0003830
Amphid wing cells, neurons having ciliated sheet-like sensory endings closely associated with amphid sheath AWAL lineage name: ABplaapapaa WBbt:0003831

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003000 lin-11 ZC247.3 Caenorhabditis elegans

8 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The stage that begins when a C.elegans individual is fully-developed and has reached maturity. adult Ce WBls:0000041
  The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch. L3 larva Ce WBls:0000035
  The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch. L2 larva Ce WBls:0000027
  The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch. L4 larva Ce WBls:0000038
  The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch. L1 larva Ce WBls:0000024
  The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo. fully-elongated embryo Ce WBls:0000021
  The C. elegans life stage spanning 350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation until elongation is over. elongating embryo Ce WBls:0000015
  The C. elegans life stage spanning 290-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage when embryo just finished gastrulation and is enclosing. enclosing embryo Ce WBls:0000013