WormMine: ExpressionPattern Expr13722

• Pattern: Using a fosmid-based reporter transgene, the previously reported expression of unc-6 in the AVG neuron up to early larval stages was corroborated. However, the expression in the AVG neurons of hermaphrodites begins to fade during the L3 stage, before sexual maturation, and is undetectable by the young adult stage. In contrast, expression is maintained in males during sexual maturation in the L4 stage into the young adult stage. Non-dimorphic unc-6 expression is observed in other neuron classes, some of which maintain unc-6 expression into adulthood (e.g., RIF neurons), whereas others do not (e.g., AVA neurons). Consistent with the expression pattern of the fosmid reporter, we observed robust unc-6 mRNA signals (single molecule FISH) in both sexes of first larval stage animals and strongly sexually dimorphic levels during sexual maturation in the L4 stage.
• Primary Identifier: Expr13722

2 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Neuron class of one ventral cord interneuron, few synapses.	AVG	lineage name: ABprpapppap	WBbt:0003850
Multi-cellular organism that can produce both male and female gametes.	hermaphrodite	hermaphroditic organism	WBbt:0007849

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00006746	unc-6	F41C6.1	Caenorhabditis elegans

2 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch.		L2 larva Ce	WBls:0000027
	The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch.		L1 larva Ce	WBls:0000024