WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

Expression Pattern :

Pattern  This experiment showed that the proximal promoter drives the expression of the gene in muscles (body-wall and vulval muscles), while the distal promoter drives its expression in ~10 of the animal's neurons (SDQL and SDQR, plus additional nonidentified head and midbody neurons. Primary Identifier  Expr8308
Remark  Authors conclude that DYC-1S is the muscle isoform and that DYC-1L is the neuronal isoform. Picture: Figure 3, Figure 4 Subcellular Localization  In neurons, this reporter gene showed a striking fluorescence pattern, consisting of a string of dots running along the axon, as shown on a midbody lateral neuron SDQR. These structures might be attachment points for the axons to the extracellular matrix beneath them. Dots were also detected in neuron cell bodies, but it is unclear whether this corresponds to the natural localization of the protein or a transgene artifact. In striated muscles the dyc-1:gfpX transgene displayed a repetitive fluorescent pattern reminiscent of the sarcomeric pattern. To identify which component of the sarcomere was labeled, authors stained dyc-1:gfpX expressing animals with the MH24 antibody, which recognizes the DEB-1/vinculin protein, one of the main components of dense bodies. The DYC-1-GFPX protein is located at the edges of MH24 labeled dense bodies.
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5 Anatomy Terms

Definition Name Synonym Primary Identifier
Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion. body wall musculature body muscle WBbt:0005813
muscle associated with hermaphrodite vulva. vulval muscle   WBbt:0005821
neuron with its cell body situated in the head, excluding the pharynx. head neuron   WBbt:0006751
Ant. lateral interneuron, process projects into ring SDQR lineage name: QR.pap WBbt:0004991
Posterior lateral interneuron, process projects into ring SDQL lineage name: QL.pap WBbt:0004993

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00001116 dyc-1 C33G3.1 Caenorhabditis elegans

0 Life Stages