WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

Expression Pattern :

Pattern  Consistent with single-cell RNA sequencing data and previous reporter analyses, we found that gpla-1 is predominantly expressed in neurons associated with the gastrointestinal tract, which are part of the enteric nervous system in C. elegans. These include the pharyngeal neurons M1, M5, I5 and NSM, as well as the excitatory motor neurons AVL and DVB that control enteric muscle contractions in the hindgut during defecation. We also observed expression of gplb-1 in the enteric DVB neuron. In addition, both gpla-1 and gplb-1 reporter transgenes show fluorescence in the RME motor neurons that innervate the head muscles. Using a reporter transgene for GABAergic neurons, we confirmed that gpla-1 and gplb-1 are both expressed in the GABAergic DVB and RME neurons. In addition, the gplb-1 reporter transgene shows expression in non-neuronal tissues, including the head mesodermal cell (hmc) and the enteric muscles of the hindgut, which are involved in defecation. Taken together, these results indicate that expression of gpla-1 and gplb-1 co-localizes in the RME neurons in the head and the enteric neuron DVB in the tail, whereas no overlapping expression is seen in the pharyngeal neurons (gpla-1) or hmc and the enteric muscles (gplb-1). Primary Identifier  Expr16471
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7 Anatomy Terms

Definition Name Synonym Primary Identifier
intestinal muscle cell, attach to intestine and body wall anterior to anus intestinal muscle stomato-intestinal muscle WBbt:0005796
Head mesodermal cell, function unknown head mesodermal cell hmc WBbt:0004697
Neuron class of one ring interneuron, cell body in dorsorectal ganglion, inervates rectal muscles. DVB lineage name: K.p WBbt:0004822
Ring motor neuron RMEL lineage name: ABalaaaarlp WBbt:0005025
Ring motor neuron RMER lineage name: ABalaaaarrp WBbt:0005023
Ring motor neuron RMED lineage name: ABalapppaap WBbt:0005027
Ring motor neuron RMEV lineage name: ABplpappaaa WBbt:0005021

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00020722 gplb-1 T23B12.8 Caenorhabditis elegans

0 Life Stages