WormMine: ExpressionPattern Expr9112

• Pattern: In the absence of any metal, numr-1 and numr-2 showed identical patterns of transcription. Both genes showed developmental patterns of expression, where maximal levels of constitutive expression were observed throughout the intestine of L1 nematodes. This expression decreased as the nematodes developed into adults, at which point it was minimal. qRT-PCR analysis confirmed that the steady-state level of numr-1/-2 mRNA was highest in L1 C. elegans and that it gradually decreased as nematodes developed into adults. In addition to developmentally regulated intestinal cell expression, numr-1 and numr-2 were constitutively expressed at all developmental stages in a few cells in the posterior of the nematode and in a pair of sensory neurons in the head. They were also constitutively expressed in egg-laying muscles of the adult vulva. To distinguish which sensory neurons expressed numr-1, JF85(mtEx60) nematodes were treated with DiI. numr-1 expression was detected in a pair of sensory neurons with processes extending towards the external environment, but the expression did not overlap with cells stained by DiI. This suggested that numr-1 was expressed in AW sensory neurons.
• Primary Identifier: Expr9112
• Remark: Picture: Fig 2.

4 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages.	intestine	gut	WBbt:0005772
muscle associated with hermaphrodite vulva.	vulval muscle		WBbt:0005821
muscle lining of the uterine wall.	uterine muscle		WBbt:0005342
neuron that senses external stimuli and transduce them to signals internal to the organism.	sensory neuron		WBbt:0005759

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00017270	numr-1	F08F8.5	Caenorhabditis elegans

0 Life Stages