WormMine: ExpressionPattern Expr14700

• Pattern: TIMP-1::Venus was detected on the gonadal basement membrane of the L3-stage larvae and on the basement membrane of somatic gonads and the plasma membrane of germ cells, including oocytes, of young adults. When CRI-2::Venus was expressed from the transgene tjTi86[cri-2p::cri-2::Venus], it also had a similar localization pattern. In the head region, TIMP-1::Venus and CRI-2::Venus localized to the basement and plasma membrane of the pharyngeal cells, and at the nerve ring. We then asked whether TIMP-1 and CRI-2 are secreted by examining the endocytic uptake of TIMP-1::Venus and CRI-2::Venus by coelomocytes, which are scavenger cells in the pseudocoelom. Accumulation of TIMP-1::Venus and CRI-2::Venus was observed in coelomocytes of these transgenic strains, suggesting that TIMP-1 and CRI-2 were secreted.
• Primary Identifier: Expr14700

4 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
the most extensive region of neuropil in the animal, consists of a large toroidal bundle of processes.	nerve ring	circumpharyngeal nerve ring	WBbt:0006749
A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles.	coelomocyte		WBbt:0005751
organ producing either sperm or ova.	gonad		WBbt:0005175
The components of the gonad that are separate from the germline proper. In hermaphrodite, these include five tissues which are all derived from the somatic primordium : the distal tip cells, the gonadal sheath, the spermatheca, the spermatheca-uterine valve (sp-ut) and the uterus.	somatic gonad	somatic germline	WBbt:0005785

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00019478	cri-2	K07C11.5	Caenorhabditis elegans

0 Life Stages